Appetitive Behavior in the Social Transmission of Food Preference Paradigm Predicts Activation of Orexin-A producing Neurons in a Sex-Dependent Manner.
appetitive behavior
infralimbic cortex
orexin/hypocretin
sex differences
social behavior
social transmission of food preference
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
12
06
2021
revised:
17
11
2021
accepted:
20
11
2021
pubmed:
30
11
2021
medline:
25
2
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
Orexin-producing cells in the lateral hypothalamic area have been shown to be involved in a wide variety of behavioral and cognitive functions, including the recall of appetitive associations and a variety of social behaviors. Here, we investigated the role of orexin in the acquisition and recall of socially transmitted food preferences in the rat. Rats were euthanized following either acquisition, short-term recall, or long-term recall of a socially transmitted food preference and their brains were processed for orexin-A and c-Fos expression. We found that while there were no significant differences in c-Fos expression between control and experimental subjects at any of the tested timepoints, females displayed significantly more activity in both orexinergic and non-orexinergic cells in the lateral hypothalamus. In the infralimbic cortex, we found that social behavior was significantly predictive of c-Fos expression, with social behaviors related to olfactory exploration appearing to be particularly influential. We additionally found that appetitive behavior was significantly predictive of orexin-A activity in a sex-dependent matter, with the total amount eaten correlating negatively with orexin-A/c-Fos colocalization in male rats but not female rats. These findings suggest a potential sex-specific role for the orexin system in balancing the stimulation of feeding behavior with the sleep/wake cycle.
Identifiants
pubmed: 34843892
pii: S0306-4522(21)00592-3
doi: 10.1016/j.neuroscience.2021.11.032
pmc: PMC9246717
mid: NIHMS1818971
pii:
doi:
Substances chimiques
Orexins
0
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-46Subventions
Organisme : NIMH NIH HHS
ID : T32 MH106454
Pays : United States
Informations de copyright
Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.
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