Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeutics.
Avacopan
C3
C5
Complement inhibitors
Complement system
Complosome
Eculizumab
Immunology
Kidney disease
Journal
Advances in immunology
ISSN: 1557-8445
Titre abrégé: Adv Immunol
Pays: United States
ID NLM: 0370425
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
30
11
2021
pubmed:
1
12
2021
medline:
29
1
2022
Statut:
ppublish
Résumé
The complement system is an ancient and phylogenetically conserved key danger sensing system that is critical for host defense against pathogens. Activation of the complement system is a vital component of innate immunity required for the detection and removal of pathogens. It is also a central orchestrator of adaptive immune responses and a constituent of normal tissue homeostasis. Once complement activation occurs, this system deposits indiscriminately on any cell surface in the vicinity and has the potential to cause unwanted and excessive tissue injury. Deposition of complement components is recognized as a hallmark of a variety of kidney diseases, where it is indeed associated with damage to the self. The provenance and the pathophysiological role(s) played by complement in each kidney disease is not fully understood. However, in recent years there has been a renaissance in the study of complement, with greater appreciation of its intracellular roles as a cell-intrinsic system and its interplay with immune effector pathways. This has been paired with a profusion of novel therapeutic agents antagonizing complement components, including approved inhibitors against complement components (C)1, C3, C5 and C5aR1. A number of clinical trials have investigated the use of these more targeted approaches for the management of kidney diseases. In this review we present and summarize the evidence for the roles of complement in kidney diseases and discuss the available clinical evidence for complement inhibition.
Identifiants
pubmed: 34844708
pii: S0065-2776(21)00030-4
doi: 10.1016/bs.ai.2021.09.001
pmc: PMC8905641
mid: NIHMS1785441
pii:
doi:
Substances chimiques
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-81Subventions
Organisme : Intramural NIH HHS
ID : ZIA DK075149
Pays : United States
Informations de copyright
2021 Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Conflicts of Interest B.A. and T.F. have no conflicts of interest to declare.
Références
Acta Pathol Microbiol Immunol Scand C. 1984 Aug;92(4):213-20
pubmed: 6391086
Kidney Int. 2003 Jan;63(1):134-42
pubmed: 12472776
Nat Rev Nephrol. 2017 Jun;13(6):359-367
pubmed: 28316335
Pediatr Nephrol. 2014 Nov;29(11):2225-8
pubmed: 24924752
Transplantation. 2003 Feb 15;75(3):375-82
pubmed: 12589162
Blood. 2014 Sep 11;124(11):1715-26
pubmed: 25037630
J Immunol. 2014 Jul 1;193(1):317-26
pubmed: 24850720
Kidney Int. 1985 Apr;27(4):643-51
pubmed: 4010151
Mol Immunol. 2020 Dec;128:195-204
pubmed: 33142137
PLoS One. 2013 Jun 13;8(6):e66305
pubmed: 23785491
Immunol Lett. 2015 Apr;164(2):117-24
pubmed: 25742728
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14490-5
pubmed: 19706534
Kidney Int. 1993 Jun;43(6):1333-8
pubmed: 8315947
J Clin Invest. 1988 Nov;82(5):1676-84
pubmed: 3183062
Blood. 2008 Sep 1;112(5):1759-66
pubmed: 18567839
Blood. 2002 Sep 1;100(5):1869-77
pubmed: 12176911
Clin J Am Soc Nephrol. 2017 May 8;12(5):825-835
pubmed: 27821390
Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931
pubmed: 30926668
J Exp Med. 2013 Feb 11;210(2):257-68
pubmed: 23382542
Nat Commun. 2018 Oct 10;9(1):4186
pubmed: 30305631
Am J Kidney Dis. 1988 Nov;12(5):348-52
pubmed: 3142256
Arch Intern Med. 2006 Oct 9;166(18):2007-13
pubmed: 17030835
J Clin Invest. 2008 Feb;118(2):608-18
pubmed: 18202746
Nephron. 1996;72(3):442-6
pubmed: 8852494
Kidney Int. 1996 Aug;50(2):521-5
pubmed: 8840281
Annu Rev Immunol. 1991;9:431-55
pubmed: 1910685
Diabetes Res. 1989 Jul;11(3):109-14
pubmed: 2697483
N Engl J Med. 2014 Dec 11;371(24):2277-2287
pubmed: 25394321
Front Immunol. 2018 Mar 19;9:559
pubmed: 29616045
Clin J Am Soc Nephrol. 2021 Jun;16(6):939-941
pubmed: 33858828
Mol Immunol. 2007 Sep;44(16):3866-74
pubmed: 17768105
N Engl J Med. 2009 Jul 2;361(1):11-21
pubmed: 19571279
Lupus. 2010 Apr;19(5):634-8
pubmed: 20071476
Am J Transplant. 2017 Mar;17(3):682-691
pubmed: 27501352
Am J Transplant. 2011 Oct;11(10):2057-66
pubmed: 21831160
Kidney Int. 2009 May;75(9):952-60
pubmed: 19177158
Nat Rev Immunol. 2021 May;21(5):319-329
pubmed: 33824483
N Engl J Med. 2019 Oct 17;381(16):1590-1592
pubmed: 31618548
Nephrol Dial Transplant. 1998 Nov;13(11):2799-803
pubmed: 9829481
Br Med J (Clin Res Ed). 1984 Oct 13;289(6450):943-5
pubmed: 6435733
Am J Pathol. 1991 Oct;139(4):717-24
pubmed: 1928296
Diabetes. 2011 Sep;60(9):2354-69
pubmed: 21752957
Nephrol Dial Transplant. 2020 Dec 4;35(12):2147-2153
pubmed: 31411695
J Am Soc Nephrol. 2010 Oct;21(10):1628-36
pubmed: 20616173
Am J Transplant. 2005 Apr;5(4 Pt 2):843-9
pubmed: 15760412
Arthritis Rheumatol. 2015 Oct;67(10):2780-90
pubmed: 26097236
Diagn Pathol. 2012 Aug 21;7:109
pubmed: 22909298
Shock. 2012 Apr;37(4):348-54
pubmed: 22258234
J Immunol. 2010 Oct 15;185(8):4738-49
pubmed: 20844193
Kidney Int. 2013 Jan;83(1):129-37
pubmed: 22913983
J Biol Chem. 2004 Jul 16;279(29):30836-43
pubmed: 15131128
Blood. 2007 Jul 1;110(1):228-36
pubmed: 17363730
Front Immunol. 2015 May 26;6:257
pubmed: 26074922
J Immunol. 2000 May 1;164(9):4522-32
pubmed: 10779753
J Pediatr. 2001 Mar;138(3):412-7
pubmed: 11241053
Immunol Res. 2006;34(2):157-76
pubmed: 16760575
Nat Immunol. 2013 Feb;14(2):162-71
pubmed: 23263555
FASEB J. 2006 Feb;20(2):217-26
pubmed: 16449793
Cell Immunol. 1986 May;99(2):507-22
pubmed: 3530508
Lancet. 2010 Jun 12;375(9731):2073-81
pubmed: 20483451
J Clin Pathol. 1993 Jul;46(7):607-10
pubmed: 8157744
J Thromb Haemost. 2005 Apr;3(4):752-62
pubmed: 15842359
J Immunol. 1985 Sep;135(3):2063-8
pubmed: 4020139
Eur J Immunol. 1996 Aug;26(8):1944-50
pubmed: 8765043
J Exp Med. 1997 May 5;185(9):1619-27
pubmed: 9151899
Pathol Int. 2007 Jun;57(6):351-7
pubmed: 17539966
Am J Transplant. 2009 Oct;9(10):2312-23
pubmed: 19681822
Clin Kidney J. 2016 Feb;9(1):90-6
pubmed: 26798467
Clin Immunol. 2006 Feb-Mar;118(2-3):127-36
pubmed: 16338172
J Immunol. 2013 Apr 1;190(7):3552-9
pubmed: 23427256
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):
pubmed: 33753502
Blood. 2008 Feb 1;111(3):1512-4
pubmed: 18006700
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8
pubmed: 20439745
Thromb Haemost. 2005 Mar;93(3):443-52
pubmed: 15735793
Blood. 1996 May 15;87(10):4235-44
pubmed: 8639782
Immunity. 2008 Mar;28(3):425-35
pubmed: 18328742
Clin J Am Soc Nephrol. 2016 Jan 7;11(1):47-53
pubmed: 26700439
J Immunol. 2009 May 15;182(10):6394-400
pubmed: 19414792
Eur J Immunol. 2011 Sep;41(9):2741-52
pubmed: 21630250
Kidney Int Rep. 2021 Jul 12;6(10):2713-2717
pubmed: 34622110
J Am Soc Nephrol. 2005 May;16(5):1214-22
pubmed: 15800113
Trends Immunol. 2007 Apr;28(4):184-92
pubmed: 17336159
J Am Soc Nephrol. 2021 May 3;32(5):1249-1261
pubmed: 33833079
Front Immunol. 2020 Oct 21;11:585243
pubmed: 33193407
J Am Soc Nephrol. 2006 Jun;17(6):1724-34
pubmed: 16687629
Mol Immunol. 2009 Sep;46(14):2767-73
pubmed: 19559484
J Clin Invest. 2019 Mar 1;129(3):1061-1075
pubmed: 30714990
Exp Diabetes Res. 2012;2012:678381
pubmed: 22645604
Eur J Immunol. 1993 Oct;23(10):2477-81
pubmed: 8405048
Clin J Am Soc Nephrol. 2012 Feb;7(2):265-74
pubmed: 22223606
J Am Soc Nephrol. 2013 Jan;24(1):53-65
pubmed: 23204401
N Engl J Med. 2009 Feb 26;360(9):874-80
pubmed: 19246358
Lupus. 2015 Mar;24(3):331-8
pubmed: 25609684
Kidney Int. 2014 Feb;85(2):450-6
pubmed: 24067430
Kidney Int. 2017 Mar;91(3):539-551
pubmed: 27989322
J Am Soc Nephrol. 2012 Jul;23(7):1229-37
pubmed: 22677550
Rheumatology (Oxford). 2016 Feb;55(2):252-62
pubmed: 26342222
Nature. 1991 Feb 14;349(6310):614-7
pubmed: 1847994
J Immunol. 1998 Mar 15;160(6):2983-97
pubmed: 9510203
Nat Rev Nephrol. 2014 Aug;10(8):445-54
pubmed: 24861083
Clin Exp Immunol. 2012 Feb;167(2):235-45
pubmed: 22235999
Nat Med. 2002 Jun;8(6):582-7
pubmed: 12042808
Blood. 2001 May 15;97(10):3100-8
pubmed: 11342436
Eur J Immunol. 2005 Aug;35(8):2496-506
pubmed: 16052609
J Am Soc Nephrol. 2015 Jul;26(7):1503-12
pubmed: 25694468
N Engl J Med. 2021 Feb 18;384(7):599-609
pubmed: 33596356
Diabetes Care. 1996 Jan;19(1):53-5
pubmed: 8720534
Nat Rev Nephrol. 2018 Jan;14(1):26-47
pubmed: 29199277
Transplantation. 2014 Nov 27;98(10):1056-9
pubmed: 24839895
J Exp Med. 2005 Mar 21;201(6):871-9
pubmed: 15781579
PLoS One. 2011 Apr 15;6(4):e18812
pubmed: 21526204
J Clin Invest. 1999 Jul;104(1):73-81
pubmed: 10393701
Diabetologia. 2007 Jul;50(7):1541-9
pubmed: 17473913
N Engl J Med. 2010 Jul 22;363(4):343-54
pubmed: 20660402
Mediators Inflamm. 2016;2016:1340156
pubmed: 27382187
N Engl J Med. 2018 Dec 20;379(25):2479-2481
pubmed: 30575481
Nephron. 1998 Dec;80(4):408-13
pubmed: 9832639
N Engl J Med. 1982 Dec 2;307(23):1432-5
pubmed: 6813740
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E534-E539
pubmed: 28069958
Mol Immunol. 2019 Oct;114:341-352
pubmed: 31446305
Mol Immunol. 2009 Sep;46(14):2753-66
pubmed: 19477527
Emerg Infect Dis. 2016 Sep;22(9):1604-12
pubmed: 27533474
Int J Pediatr Nephrol. 1985 Jan-Mar;6(1):17-24
pubmed: 3997368
J Am Soc Nephrol. 2012 Sep;23(9):1474-85
pubmed: 22797180
Lupus. 2020 Oct;29(11):1456-1460
pubmed: 32659156
Nat Genet. 1998 May;19(1):56-9
pubmed: 9590289
Nephrol Dial Transplant. 2017 Aug 01;32(8):1302-1313
pubmed: 26275893
J Am Soc Nephrol. 2009 Mar;20(3):593-603
pubmed: 19158354
J Am Soc Nephrol. 2002 Mar;13(3):779-787
pubmed: 11856785
Pediatr Nephrol. 2018 Aug;33(8):1297-1307
pubmed: 28748411
J Immunol. 2000 Jan 15;164(2):786-94
pubmed: 10623824
Kidney Int. 2020 Nov;98(5):1253-1264
pubmed: 32534052
J Immunol. 2009 Sep 15;183(6):3980-8
pubmed: 19710463
Kidney Int. 2015 Nov;88(5):1153-60
pubmed: 26221755
ACR Open Rheumatol. 2020 Nov;2(11):662-671
pubmed: 33128347
Immunity. 2021 May 11;54(5):1002-1021.e10
pubmed: 33761330
Lancet Neurol. 2017 Dec;16(12):976-986
pubmed: 29066163
J Am Soc Nephrol. 1999 Nov;10(11):2446-53
pubmed: 10541306
Nephrol Dial Transplant. 2009 Jan;24(1):62-72
pubmed: 18685143
Am J Physiol Renal Physiol. 2005 Oct;289(4):F660-71
pubmed: 16159900
Kidney Int. 1989 Dec;36(6):1069-77
pubmed: 2689750
Ann Rheum Dis. 2019 Jun;78(6):736-745
pubmed: 30926722
Front Med (Lausanne). 2014 Dec 12;1:52
pubmed: 25593925
Am J Kidney Dis. 2015 Sep;66(3):e15-7
pubmed: 26300203
J Am Soc Nephrol. 2013 Jan;24(1):43-52
pubmed: 23184055
Am J Transplant. 2015 Sep;15(9):2421-30
pubmed: 25930984
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3357-61
pubmed: 8622941
Diabetologia. 2016 Apr;59(4):853-8
pubmed: 26768002
Diabetes Metab Res Rev. 2010 May;26(4):254-60
pubmed: 20503257
J Immunol. 2008 Sep 1;181(5):2953-9
pubmed: 18713965
PLoS One. 2012;7(5):e38317
pubmed: 22675451
Am J Kidney Dis. 2020 Jan;75(1 Suppl 1):A6-A7
pubmed: 31704083
Pediatr Nephrol. 2011 Feb;26(2):165-80
pubmed: 20652330
Am J Kidney Dis. 2000 Jul;36(1):153-9
pubmed: 10873885
J Autoimmun. 2009 Mar;32(2):85-93
pubmed: 19200691
Clin Exp Immunol. 2018 Jan;191(1):116-124
pubmed: 28940198
J Exp Med. 2007 Jun 11;204(6):1249-56
pubmed: 17517971
Nat Immunol. 2012 Dec;13(12):1213-21
pubmed: 23086448
J Thromb Haemost. 2012 May;10(5):791-8
pubmed: 22372946
Transplant Proc. 2017 Sep;49(7):1574-1577
pubmed: 28838443
J Clin Invest. 2004 Sep;114(5):679-88
pubmed: 15343386
Int J Rheum Dis. 2009 Dec;12(4):293-8
pubmed: 20374365
Int J Clin Exp Pathol. 2013 Sep 15;6(10):2157-67
pubmed: 24133594
Curr Opin Nephrol Hypertens. 2012 May;21(3):235-42
pubmed: 22388552
Am J Kidney Dis. 2015 Mar;65(3):484-9
pubmed: 25530108
J Am Soc Nephrol. 2020 Sep;31(9):1977-1986
pubmed: 32669324
Pediatr Nephrol. 2018 Aug;33(8):1385-1394
pubmed: 29572749
Sci Immunol. 2021 Apr 7;6(58):
pubmed: 33827897
Diabetologia. 2014 Oct;57(10):2201-7
pubmed: 25064124
Annu Rev Immunol. 2003;21:547-78
pubmed: 12524383
Am J Transplant. 2011 Oct;11(10):2123-31
pubmed: 21827618
Science. 1996 Jan 19;271(5247):348-50
pubmed: 8553069
Nephron Clin Pract. 2004;97(4):c147-53
pubmed: 15331938
Clin Proteomics. 2017 Aug 14;14:30
pubmed: 28814945
Am J Transplant. 2003 Jun;3(6):708-14
pubmed: 12780562
Kidney Int. 2007 Jun;71(11):1094-104
pubmed: 17342179
J Am Soc Nephrol. 2019 Jun;30(6):1123-1136
pubmed: 31061139
Can J Kidney Health Dis. 2021 Apr 22;8:20543581211008707
pubmed: 33996107
Diabetes. 1974 Sep;23(9):748-53
pubmed: 4278212
Nat Genet. 2011 Mar 13;43(4):321-7
pubmed: 21399633
Blood. 2013 Mar 7;121(10):1760-8
pubmed: 23299310
Immunol Rev. 2016 Nov;274(1):245-269
pubmed: 27782319
Eur J Biochem. 1993 Oct 1;217(1):289-94
pubmed: 8223566
J Biol Chem. 2002 Mar 1;277(9):7165-9
pubmed: 11773063
J Am Soc Nephrol. 2011 Feb;22(2):296-305
pubmed: 21088295
J Immunol. 1996 Jun 1;156(11):4415-21
pubmed: 8666815
Br J Haematol. 2018 Mar;180(6):782-798
pubmed: 29265338
J Am Soc Nephrol. 2018 Sep;29(9):2279-2285
pubmed: 30049681
Scand J Immunol. 2005 May;61(5):426-34
pubmed: 15882434
Semin Nephrol. 2013 Nov;33(6):531-42
pubmed: 24161038
J Am Soc Nephrol. 2017 Nov;28(11):3262-3277
pubmed: 28814510
Kidney Int. 1987 Mar;31(3):820-9
pubmed: 3573542
Kidney Int. 2003 Jun;63(6):2286-94
pubmed: 12753320
J Am Soc Nephrol. 2016 Sep;27(9):2894-905
pubmed: 26825529
Muscle Nerve. 2019 Jul;60(1):14-24
pubmed: 30767274
J Immunol. 2004 Mar 15;172(6):3869-75
pubmed: 15004194
J Clin Endocrinol Metab. 2014 Jun;99(6):E999-E1006
pubmed: 24628556
Am J Physiol Renal Physiol. 2008 Apr;294(4):F945-55
pubmed: 18256312
Sci Signal. 2010 Feb 16;3(109):ra11
pubmed: 20159852
Clin J Am Soc Nephrol. 2009 Dec;4(12):1920-4
pubmed: 19820137
Ann Rheum Dis. 2014 Sep;73(9):1601-6
pubmed: 24845390
Front Pharmacol. 2021 Jan 21;11:591398
pubmed: 33551801
N Engl J Med. 1988 May 19;318(20):1289-92
pubmed: 3283557
Front Immunol. 2015 Jun 02;6:262
pubmed: 26082779
J Am Soc Nephrol. 2000 Apr;11(4):700-707
pubmed: 10752529
Diabetes. 2004 Oct;53(10):2653-61
pubmed: 15448097
Clin Exp Nephrol. 2019 Feb;23(2):169-181
pubmed: 30066158
Clin Exp Immunol. 2017 May;188(2):183-194
pubmed: 28249350
Am J Pathol. 2018 Oct;188(10):2147-2154
pubmed: 30253844
Ann Rheum Dis. 2007 Dec;66(12):1679-82
pubmed: 17644551
Blood. 2021 May 6;137(18):2438-2449
pubmed: 33270832
Diabetes Care. 2015 Oct;38(10):1898-903
pubmed: 26180106
Rheumatology (Oxford). 2018 Dec 1;57(12):2213-2224
pubmed: 29471467
Immunity. 2015 Jun 16;42(6):1033-47
pubmed: 26084023
Pediatr Infect Dis J. 2009 Jul;28(7):650-3
pubmed: 19483660
Blood. 2017 Mar 2;129(9):1184-1196
pubmed: 28057640
J Immunol. 2005 Oct 1;175(7):4706-14
pubmed: 16177118
J Am Soc Nephrol. 2006 Dec;17(12):3520-8
pubmed: 17093066
Lancet. 1993 Nov 20;342(8882):1273-4
pubmed: 7901586
Nat Rev Immunol. 2019 Aug;19(8):503-516
pubmed: 31048789
Kidney Int. 2006 Jan;69(2):272-80
pubmed: 16408116
Nat Rev Microbiol. 2010 Feb;8(2):105-16
pubmed: 20023663
Annu Rev Immunol. 2004;22:431-56
pubmed: 15032584
J Immunol. 2019 Jun 15;202(12):3339-3348
pubmed: 31160390
Immunology. 1993 Jul;79(3):348-54
pubmed: 8406564
Arthritis Res Ther. 2012 Jun 12;14(3):R140
pubmed: 22691190
Kidney Int. 2003 Oct;64(4):1535-50
pubmed: 12969182
J Am Soc Nephrol. 2009 Feb;20(2):289-98
pubmed: 19073822
J Am Soc Nephrol. 2001 Jul;12(7):1383-1390
pubmed: 11423567
Nat Rev Immunol. 2018 Feb;18(2):134-147
pubmed: 28990587
Scand J Immunol. 2013 Mar;77(3):187-94
pubmed: 23350935
J Immunol. 2007 Aug 15;179(4):2600-8
pubmed: 17675523
Kidney Int. 1996 Aug;50(2):635-42
pubmed: 8840296
Am J Transplant. 2005 May;5(5):1071-5
pubmed: 15816888
Am J Clin Pathol. 2006 Mar;125(3):445-50
pubmed: 16613350
Science. 2018 May 4;360(6388):558-563
pubmed: 29724957
Blood. 2002 Jan 1;99(1):185-92
pubmed: 11756170
Curr Opin Nephrol Hypertens. 1999 May;8(3):299-306
pubmed: 10456260
J Immunol. 2003 Feb 1;170(3):1517-23
pubmed: 12538716
Kidney Int. 2007 Apr;71(7):646-54
pubmed: 17299525
Front Immunol. 2019 Sep 27;10:2166
pubmed: 31611870
Kidney Int Rep. 2020 Jan 30;5(5):618-626
pubmed: 32405583
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9023-8
pubmed: 18579773
Immunol Rev. 2016 Nov;274(1):74-97
pubmed: 27782323
Semin Immunopathol. 2018 Jan;40(1):75-85
pubmed: 28894916
N Engl J Med. 2008 Jun 5;358(23):2433-46
pubmed: 18525041
Blood. 2011 May 19;117(20):5503-13
pubmed: 21447825
N Engl J Med. 2001 Apr 5;344(14):1058-66
pubmed: 11287977
Circulation. 2007 Oct 23;116(17):1896-906
pubmed: 17923576
J Am Soc Nephrol. 2021 May 5;:
pubmed: 33952630
Clin Nephrol. 2011 Apr;75(4):271-8
pubmed: 21426880
BMC Nephrol. 2019 Nov 21;20(1):424
pubmed: 31752725
J Am Soc Nephrol. 2018 Dec;29(12):2809-2819
pubmed: 30377230
Nephrol Dial Transplant. 2011 Jul;26(7):2345-54
pubmed: 21127132
Semin Nephrol. 2013 Nov;33(6):479-92
pubmed: 24161035
Pediatr Nephrol. 1988 Apr;2(2):219-23
pubmed: 3153014
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):240-5
pubmed: 17182750
Am J Kidney Dis. 1992 Aug;20(2):144-9
pubmed: 1496967
PLoS One. 2013 Dec 20;8(12):e83059
pubmed: 24376633
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5450-5
pubmed: 10805801
J Exp Med. 1993 Aug 1;178(2):661-7
pubmed: 8340761
Immunology. 1994 Jan;81(1):137-41
pubmed: 8132210
Am J Kidney Dis. 2018 Jul;72(1):84-92
pubmed: 29429752
Mediators Inflamm. 2015;2015:653260
pubmed: 26339138
J Immunol. 1977 Jun;118(6):2192-8
pubmed: 864257
Front Immunol. 2020 Dec 10;11:599417
pubmed: 33362783
Arch Dis Child. 1984 Dec;59(12):1135-40
pubmed: 6441524
J Exp Med. 1974 Apr 1;139(4):793-800
pubmed: 4273909
Am J Pathol. 2002 Dec;161(6):2027-34
pubmed: 12466119
Lancet. 2005 Mar 19-25;365(9464):1073-86
pubmed: 15781103
Nat Rev Nephrol. 2014 Apr;10(4):193-207
pubmed: 24445744
Pediatr Nephrol. 2020 Sep;35(9):1749-1759
pubmed: 32323005
J Clin Invest. 1993 Sep;92(3):1451-8
pubmed: 8376597
Nephrol Ther. 2019 Nov;15(6):409-412
pubmed: 31631015
Nat Rev Nephrol. 2020 Apr;16(4):206-222
pubmed: 31942046
JCI Insight. 2020 May 7;5(9):
pubmed: 32376801
J Am Soc Nephrol. 2016 Dec;27(12):3539-3544
pubmed: 27153925
J Immunol. 2012 May 15;188(10):5086-93
pubmed: 22491257
Mol Immunol. 2007 Jul;44(13):3389-97
pubmed: 17383729
Clin J Am Soc Nephrol. 2013 Mar;8(3):407-15
pubmed: 23243267
Nat Rev Nephrol. 2021 Aug;17(8):543-553
pubmed: 33953366
J Leukoc Biol. 2007 Jun;81(6):1404-13
pubmed: 17389579
Immunity. 2013 Dec 12;39(6):1143-57
pubmed: 24315997
Curr Opin Nephrol Hypertens. 2011 Mar;20(2):153-60
pubmed: 21301336
Kidney Int. 2005 Feb;67(2):524-30
pubmed: 15673300
J Clin Invest. 2017 Mar 1;127(3):970-981
pubmed: 28192370
Science. 1998 Apr 24;280(5363):582-5
pubmed: 9554848
Thromb Res. 2014 May;133 Suppl 1:S28-31
pubmed: 24759136
Clin J Am Soc Nephrol. 2018 Feb 7;13(2):258-264
pubmed: 29146701
J Diabetes Investig. 2019 May;10(3):738-744
pubmed: 30239170
Mol Immunol. 2010 Apr;47(7-8):1476-83
pubmed: 20193965
J Nephrol. 2016 Apr;29(2):203-209
pubmed: 26187133
J Clin Invest. 2021 Mar 1;131(5):
pubmed: 33351779
Br Med J. 1973 Sep 29;3(5882):668-72
pubmed: 4200478
Virchows Arch. 2020 Oct;477(4):565-572
pubmed: 32300880
Am J Respir Crit Care Med. 2006 Apr 15;173(8):852-7
pubmed: 16439722
Am J Kidney Dis. 2004 Aug;44(2):224-38
pubmed: 15264180
Nat Immunol. 2021 Jun;22(6):757-768
pubmed: 34031614
Eur J Immunol. 1999 Sep;29(9):3035-46
pubmed: 10508278
J Immunol. 2013 Jun 15;190(12):5921-5
pubmed: 23690475
Nephrol Dial Transplant. 2006 Nov;21(11):3115-21
pubmed: 16877491
J Clin Invest. 2010 Oct;120(10):3702-12
pubmed: 20852386
Nature. 2003 Jan 23;421(6921):388-92
pubmed: 12540904
J Clin Invest. 2000 May;105(10):1363-71
pubmed: 10811844
Nat Genet. 2002 Aug;31(4):424-8
pubmed: 12091909
J Immunol. 2021 Jul 15;207(2):534-541
pubmed: 34193601
J Am Soc Nephrol. 2005 May;16(5):1195-204
pubmed: 15800119
Am J Transplant. 2007 Jul;7(7):1743-52
pubmed: 17564636
J Am Soc Nephrol. 2018 Feb;29(2):620-635
pubmed: 29042454
N Engl J Med. 2013 Sep 26;369(13):1215-26
pubmed: 24066742
Am J Transplant. 2020 Jun;20(6):1513-1526
pubmed: 31922336
J Clin Invest. 2006 Feb;116(2):357-68
pubmed: 16444293
Science. 1992 Apr 3;256(5053):105-7
pubmed: 1373518
Kidney Int. 1998 Feb;53(2):331-49
pubmed: 9461093
J Immunol. 2012 Apr 1;188(7):3522-31
pubmed: 22345666
Diabetes. 2009 Jul;58(7):1710-4
pubmed: 19366862
J Am Soc Nephrol. 2020 Apr;31(4):829-840
pubmed: 32034108
Kidney Int Rep. 2021 Mar 24;6(6):1603-1613
pubmed: 34169200
Kidney Int. 2009 Sep;76(5):534-45
pubmed: 19571791
Nat Rev Drug Discov. 2019 Sep;18(9):707-729
pubmed: 31324874
J Clin Invest. 2016 May 2;126(5):1911-25
pubmed: 27088797
Lancet. 2016 May 14;387(10032):2036-48
pubmed: 26921911
Nat Rev Nephrol. 2018 Dec;14(12):767-781
pubmed: 30367174
Am J Pathol. 2004 Nov;165(5):1677-88
pubmed: 15509537
Semin Immunopathol. 2018 Jan;40(1):87-102
pubmed: 28900700
Sci Rep. 2021 Mar 9;11(1):5467
pubmed: 33750830
Blood. 2006 Aug 15;108(4):1267-79
pubmed: 16621965
Clin Pediatr (Phila). 2013 Jul;52(7):599-607
pubmed: 23610239
J Am Soc Nephrol. 1999 Oct;10(10):2208-14
pubmed: 10505698
N Engl J Med. 2021 Mar 18;384(11):1028-1037
pubmed: 33730455
Nature. 2001 Oct 4;413(6855):488-94
pubmed: 11586351
Nat Med. 2003 Feb;9(2):206-12
pubmed: 12514742
Ann Intern Med. 1971 Oct;75(4):555-60
pubmed: 4106150
J Biol Chem. 1999 Mar 26;274(13):8367-70
pubmed: 10085065
Blood. 2014 Oct 30;124(18):2804-11
pubmed: 25237200
Mol Immunol. 2014 Mar;58(1):98-107
pubmed: 24321396
Pediatr Nephrol. 1994 Dec;8(6):671-6
pubmed: 7696103
J Immunol. 2001 Sep 1;167(5):2861-8
pubmed: 11509633
Semin Nephrol. 2013 Nov;33(6):543-56
pubmed: 24161039
PLoS One. 2014 Nov 25;9(11):e113639
pubmed: 25422985
PLoS One. 2011 Jan 19;6(1):e16287
pubmed: 21283821
Clin Exp Nephrol. 2021 Jun;25(6):641-651
pubmed: 33620604
N Engl J Med. 2013 Jun 20;368(25):2402-14
pubmed: 23782179
J Clin Invest. 1995 Mar;95(3):1054-61
pubmed: 7883953
N Engl J Med. 1991 Aug 8;325(6):393-7
pubmed: 2062330
PLoS Genet. 2011 May;7(5):e1002079
pubmed: 21637784
J Immunol. 2008 Oct 1;181(7):5158-66
pubmed: 18802120
Nephrol Dial Transplant. 1995;10(7):1166-72
pubmed: 7478119
J Immunol. 2015 Apr 15;194(8):3542-8
pubmed: 25848071
Nat Immunol. 2000 Sep;1(3):221-6
pubmed: 10973279
Br J Haematol. 2012 Jun;157(6):772-4
pubmed: 22409250
J Am Soc Nephrol. 2016 Apr;27(4):1245-53
pubmed: 26283675
Blood. 2002 Nov 15;100(10):3626-32
pubmed: 12393399
Arthritis Rheum. 1996 Jun;39(6):894-903
pubmed: 8651982
Kidney Int. 2011 Jul;80(2):165-73
pubmed: 21544060
Am J Transplant. 2009 Jan;9(1):231-5
pubmed: 18976298
PLoS One. 2015 Mar 24;10(3):e0119699
pubmed: 25803807
Science. 2016 Jun 17;352(6292):aad1210
pubmed: 27313051
Immunity. 2005 Apr;22(4):415-26
pubmed: 15845447
Dev Comp Immunol. 2001 Oct-Dec;25(8-9):745-62
pubmed: 11602194
Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F821-34
pubmed: 26311114
Clin Exp Immunol. 1997 Dec;110(3):403-9
pubmed: 9409643
Blood. 2008 Feb 15;111(4):1840-7
pubmed: 18055865
Pediatr Nephrol. 2010 Jun;25(6):1091-9
pubmed: 20151159
J Immunol Res. 2019 Dec 30;2019:1324804
pubmed: 32083137
Nephron. 1999 Feb;81(2):208-14
pubmed: 9933757
Clin Nephrol. 1984 Jun;21(6):335-40
pubmed: 6205804
Nephron Exp Nephrol. 2011;119(1):e8-20
pubmed: 21606656
Pediatr Nephrol. 2019 Sep;34(9):1485-1492
pubmed: 30058046
J Transl Med. 2016 Sep 23;14(1):277
pubmed: 27663514
Blood. 2008 Dec 15;112(13):4948-52
pubmed: 18796626
Blood. 2013 Nov 14;122(20):3473-81
pubmed: 23878142
Kidney Int. 2018 Oct;94(4):689-700
pubmed: 29884545
J Immunol. 1988 Feb 1;140(3):899-904
pubmed: 2963069
Pediatr Nephrol. 1992 Mar;6(2):123-30
pubmed: 1571205
J Am Soc Nephrol. 2013 Jun;24(7):1063-72
pubmed: 23641055
J Rheumatol. 2003 Jul;30(7):1495-504
pubmed: 12858447
Immunobiology. 2012 Jan;217(1):65-73
pubmed: 21855168
Immunobiology. 2002 Sep;205(4-5):407-20
pubmed: 12396003
Arthritis Rheum. 2001 Aug;44(8):1836-40
pubmed: 11508436
Nature. 1988 Apr 21;332(6166):738-40
pubmed: 3258649
PLoS Genet. 2007 Mar 16;3(3):e41
pubmed: 17367211
Nat Rev Nephrol. 2017 May;13(5):311-318
pubmed: 28262777
Kidney Int. 2004 Jan;65(1):129-38
pubmed: 14675043
J Am Soc Nephrol. 2000 Jan;11(1):25-38
pubmed: 10616837
Clin J Am Soc Nephrol. 2013 Sep;8(9):1482-93
pubmed: 23744003
Saudi J Kidney Dis Transpl. 2018 May-Jun;29(3):728-731
pubmed: 29970754
Am J Transplant. 2016 Dec;16(12):3468-3478
pubmed: 27184779
Springer Semin Immunopathol. 2005 Nov;27(3):345-58
pubmed: 16200405
Immunity. 2020 Mar 17;52(3):513-527.e8
pubmed: 32187519
Nephrol Dial Transplant. 2018 Aug 1;33(8):1323-1332
pubmed: 29294056
Nephrol Dial Transplant. 2002 May;17(5):745-52
pubmed: 11981058
Am J Kidney Dis. 2010 Dec;56(6):1168-74
pubmed: 20843591
Clin J Am Soc Nephrol. 2013 Nov;8(11):1884-91
pubmed: 24115193
J Clin Immunol. 2009 May;29(3):282-91
pubmed: 19067130
PLoS One. 2014 Mar 21;9(3):e91250
pubmed: 24658070
Metabolism. 2015 May;64(5):597-610
pubmed: 25682062
J Immunol. 1994 Aug 15;153(4):1430-40
pubmed: 8046223
Diabetes Metab. 2019 Sep;45(4):363-368
pubmed: 30243617
Kidney Int. 1984 Jun;25(6):937-41
pubmed: 6236326
JCI Insight. 2017 Aug 17;2(16):
pubmed: 28814669
Am J Transplant. 2016 Sep;16(9):2589-97
pubmed: 27003920
J Clin Immunol. 2013 Jan;33(1):172-8
pubmed: 22941511
Pediatr Nephrol. 2014 Jun;29(6):1107-11
pubmed: 24408225
Scand J Infect Dis. 1999;31(6):523-37
pubmed: 10680980
Clin Exp Immunol. 1997 Jan;107(1):1-7
pubmed: 9010248
J Immunol. 2005 Aug 1;175(3):1947-55
pubmed: 16034139
Thromb Haemost. 2012 Dec;108(6):1141-53
pubmed: 23014597
Pediatr Nephrol. 2016 Nov;31(11):2079-86
pubmed: 27008643
Cytokine. 1997 Apr;9(4):276-83
pubmed: 9112336
N Engl J Med. 2011 Nov 10;365(19):1771-80
pubmed: 21696328
Arthritis Rheum. 2009 Oct;60(10):3081-90
pubmed: 19790049
Mayo Clin Proc. 2018 Aug;93(8):991-1008
pubmed: 30077216
J Clin Invest. 1991 Aug;88(2):379-84
pubmed: 1864952
Kidney Int. 1998 Mar;53(3):609-16
pubmed: 9507205
Clin Kidney J. 2015 Oct;8(5):489-91
pubmed: 26413271
Lancet. 2010 Sep 4;376(9743):794-801
pubmed: 20800271
Am J Pathol. 2007 Jan;170(1):52-64
pubmed: 17200182
Kidney Int. 1979 Oct;16(4):505-12
pubmed: 398417
Semin Cell Biol. 1995 Oct;6(5):275-82
pubmed: 8562920
FASEB J. 2014 Sep;28(9):3996-4003
pubmed: 24868011
J Am Soc Nephrol. 2017 Sep;28(9):2756-2767
pubmed: 28400446
J Am Soc Nephrol. 2014 Feb;25(2):225-31
pubmed: 24179165
Nat Immunol. 2019 Jul;20(7):902-914
pubmed: 31209404
Transplant Direct. 2019 Mar 25;5(4):e341
pubmed: 30993186
Biochem J. 1983 Feb 15;210(2):567-76
pubmed: 6222733
PLoS One. 2018 Jan 11;13(1):e0191292
pubmed: 29324883
Blood. 2001 Sep 15;98(6):1765-72
pubmed: 11535510
Kidney Int. 2012 Aug;82(4):454-64
pubmed: 22456601
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9649-54
pubmed: 16769899
J Clin Invest. 2002 Oct;110(7):955-63
pubmed: 12370273
Am J Transplant. 2012 Mar;12(3):660-8
pubmed: 22176838
J Immunol. 1998 Jun 15;160(12):6128-36
pubmed: 9637530
J Am Soc Nephrol. 1998 Aug;9(8):1526-34
pubmed: 9697677
Clin Chim Acta. 2018 Jul;482:65-73
pubmed: 29604259
J Am Soc Nephrol. 2005 Feb;16(2):555-63
pubmed: 15590760
Autoimmun Rev. 2015 Mar;14(3):246-53
pubmed: 25462583
Nat Med. 2009 Jun;15(6):623-5
pubmed: 19448636
BMC Nephrol. 2019 Aug 9;20(1):313
pubmed: 31399080
Mol Immunol. 1996 Jul;33(10):847-54
pubmed: 8845016
N Engl J Med. 2006 May 11;354(19):2014-23
pubmed: 16687714
Immunobiology. 2011 Jan-Feb;216(1-2):96-102
pubmed: 20399528
J Am Soc Nephrol. 2005 Jul;16(7):2003-11
pubmed: 15872081
Kidney Int. 2020 Jan;97(1):163-174
pubmed: 31901340
Nat Rev Nephrol. 2019 Mar;15(3):129-143
pubmed: 30692664
Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2143-51
pubmed: 26542163
J Clin Endocrinol Metab. 2003 Oct;88(10):4857-61
pubmed: 14557465
Clin Exp Immunol. 1991 Dec;86(3):464-70
pubmed: 1747954
Clin Exp Immunol. 2006 Jul;145(1):21-7
pubmed: 16792669
Immunobiology. 2014 Dec;219(12):980-9
pubmed: 25092568
Am J Kidney Dis. 2009 Jun;53(6):1098-101
pubmed: 19084308
Kidney Int. 2020 Jun;97(6):1287-1296
pubmed: 32299680
Kidney Int. 2017 Nov;92(5):1232-1241
pubmed: 28712854
J Diabetes Res. 2016;2016:1825738
pubmed: 26977416
Trends Immunol. 2016 Dec;37(12):844-854
pubmed: 27793570
Annu Rev Immunol. 2014;32:433-59
pubmed: 24499275
BMC Nephrol. 2020 Jun 30;21(1):245
pubmed: 32605540
J Immunol. 1978 Sep;121(3):1025-30
pubmed: 690431
Kidney Int. 2001 Sep;60(3):831-46
pubmed: 11532079
Clin Exp Immunol. 1993 Sep;93(3):411-7
pubmed: 8370168
J Immunol. 2018 Apr 1;200(7):2464-2478
pubmed: 29500241
J Am Soc Nephrol. 2011 Aug;22(8):1551-9
pubmed: 21784901
Diabetologia. 2010 Jul;53(7):1517-24
pubmed: 20396997
EMBO J. 2015 Nov 12;34(22):2735-57
pubmed: 26489954
Front Genet. 2021 Jun 11;12:670727
pubmed: 34211499
J Am Soc Nephrol. 2015 Feb;26(2):457-67
pubmed: 25125383
N Engl J Med. 2013 Jun 6;368(23):2169-81
pubmed: 23738544
Sci Immunol. 2017 Jan;2(7):
pubmed: 28529998
Immunobiology. 2007;212(4-5):289-99
pubmed: 17544814
Transpl Int. 2014 Dec;27(12):1235-43
pubmed: 24990476
N Engl J Med. 2009 Jul 23;361(4):345-57
pubmed: 19625716
Clin Exp Immunol. 2015 May;180(2):227-32
pubmed: 25533914
Lancet. 2013 Mar 2;381(9868):727-34
pubmed: 23261146
Am J Transplant. 2015 May;15(5):1293-302
pubmed: 25731800
Am J Pathol. 2000 Sep;157(3):825-31
pubmed: 10980122
Transplantation. 2020 May;104(5):911-922
pubmed: 31895348
Clin J Am Soc Nephrol. 2014 May;9(5):897-904
pubmed: 24578331
Am J Kidney Dis. 1994 Mar;23(3):451-62
pubmed: 8128950
J Immunol. 2013 Oct 15;191(8):4308-16
pubmed: 24043889
JAMA. 1994 Nov 2;272(17):1349-53
pubmed: 7933395
Pediatr Nephrol. 2015 Jun;30(6):1033-7
pubmed: 25796589
Nephrology (Carlton). 2020 Apr;25(4):351-359
pubmed: 31707756
Blood. 1996 May 15;87(10):4223-34
pubmed: 8639781
J Infect Dis. 2001 Apr 1;183(7):1063-70
pubmed: 11237831
N Engl J Med. 2011 Dec 15;365(24):2340-2
pubmed: 22168663
Nat Immunol. 2010 Sep;11(9):862-71
pubmed: 20694009
Kidney Int. 1992 Sep;42(3):573-85
pubmed: 1383596
Kidney Int. 2018 Mar;93(3):615-625
pubmed: 29241626
Nat Med. 2006 Jun;12(6):682-7
pubmed: 16715088
Mol Immunol. 2014 Mar;58(1):77-84
pubmed: 24317278
J Am Soc Nephrol. 2017 Apr;28(4):1306-1313
pubmed: 27821627
Diabetes. 1975 Mar;24(3):280-5
pubmed: 123209
J Immunol. 2011 Jul 1;187(1):172-80
pubmed: 21642543
Nephrol Dial Transplant. 1998 Aug;13(8):1984-90
pubmed: 9719152
Clin Exp Immunol. 2008 Jul;153(1):117-26
pubmed: 18505432
Kidney Int. 2018 Dec;94(6):1141-1150
pubmed: 30322716
Hum Mol Genet. 2005 Mar 1;14(5):703-12
pubmed: 15661753
N Engl J Med. 2015 Dec 3;373(23):2225-36
pubmed: 26630142
Transplantation. 2012 May 15;93(9):867-73
pubmed: 22361472
Br J Exp Pathol. 1974 Feb;55(1):47-55
pubmed: 4275643
Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F584-F592
pubmed: 31291122
J Am Soc Nephrol. 1995 May;5(11):1888-94
pubmed: 7620086