Redrawing therapeutic boundaries: microbiota and cancer.
biomarkers
cancer
causality
microbiota
network medicine
therapeutic modulation
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
04
09
2021
accepted:
28
10
2021
pubmed:
1
12
2021
medline:
2
4
2022
entrez:
30
11
2021
Statut:
ppublish
Résumé
The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host's proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer-microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the microbiota's causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology.
Identifiants
pubmed: 34844910
pii: S2405-8033(21)00225-9
doi: 10.1016/j.trecan.2021.10.008
pmc: PMC8770609
mid: NIHMS1759898
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-97Subventions
Organisme : NCI NIH HHS
ID : F30 CA243480
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA241728
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA248454
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests G.D.S-P. and R.K. are inventors on a US patent application (PCT/US2019/059647) submitted by the Regents of the University of California and licensed by Micronoma; that application covers methods of diagnosing and treating cancer using microbial biomarkers in blood and cancer tissues. G.D.S-P. and R.K. are founders of and report stock interest in Micronoma. G.D.S-P. has filed several additional US patent applications on cancer microbiome diagnostics that are owned by the Regents of the University of California. R.K. additionally is a member of the scientific advisory board for GenCirq, holds an equity interest in GenCirq, and can receive reimbursements for expenses up to US $5000 per year.
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