The Role of the Natural Antioxidant Mechanism in Sperm Cells.
Antioxidants
Cell
Mechanism
Reproduction
Spermatozoa
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
14
03
2021
accepted:
03
11
2021
pubmed:
1
12
2021
medline:
15
4
2022
entrez:
30
11
2021
Statut:
ppublish
Résumé
Molecular studies of the causes of male infertility revealed a significant contribution of oxidative stress. When excessive amounts of reactive oxygen species (ROS) are produced or antioxidant activity fails, the equilibrium between oxidation and reduction is disrupted, causing oxidative stress (OS). High levels of ROS can have an adverse effect on sperm function through the initiation of DNA damage, lipid peroxidation, loss of membrane integrity and increased permeability, inactivation of cellular enzymes, and cell apoptosis. In addition to endogenous factors such as immature sperm, leukocytes, and varicocele, potential causes of excessive ROS can also be found exogenously in males with testicular hyperthermia or exposed to environmental toxicity. To maintain the optimal functioning of sperm cells, it is, therefore, necessary to balance the redox potential, i.e., to balance ROS by antioxidants. The purpose of this review is to present the antioxidant defense systems in semen.
Identifiants
pubmed: 34845666
doi: 10.1007/s43032-021-00795-w
pii: 10.1007/s43032-021-00795-w
pmc: PMC9005387
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1387-1394Informations de copyright
© 2021. The Author(s).
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