Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.

Animals Caco-2 Cells Cell Death / physiology Colitis / metabolism Epithelial Cells / metabolism Hexokinase / metabolism Histone Deacetylases / metabolism Humans Mice Mitochondria / metabolism Repressor Proteins / metabolism
HK2 butyrate hexokinase immunometabolism inflammation intestinal epithelial cell microbiota

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
07 12 2021
Historique:
received: 27 01 2021
revised: 07 08 2021
accepted: 09 11 2021
pubmed: 1 12 2021
medline: 8 4 2022
entrez: 30 11 2021
Statut: ppublish

Résumé

Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact on inflammation using mice lacking HK2 in intestinal epithelial cells (Hk2

Identifiants

DOI: 10.1016/j.cmet.2021.11.004 PMID: 34847376
pubmed: 34847376
pii: S1550-4131(21)00532-5
doi: 10.1016/j.cmet.2021.11.004
pii:
doi:

Substances chimiques

Repressor Proteins 0
Hexokinase EC 2.7.1.1
HDAC8 protein, human EC 3.5.1.98
Histone Deacetylases EC 3.5.1.98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2355-2366.e8

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI148465
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Finn Hinrichsen (F)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Jacob Hamm (J)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Magdalena Westermann (M)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Lena Schröder (L)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Kensuke Shima (K)

Department of Infectious Diseases and Microbiology, University of Lübeck, 23538 Lübeck, Germany.

Neha Mishra (N)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Alesia Walker (A)

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, German Research Centre for Environmental Health (GmbH), 85764 Neuherberg, Germany.

Nina Sommer (N)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Kenneth Klischies (K)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Daniela Prasse (D)

Institute of General Microbiology, University of Kiel, 24118 Kiel, Germany.

Johannes Zimmermann (J)

Institute of Experimental Medicine, University of Kiel, 24105 Kiel, Germany.

Sina Kaiser (S)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Dora Bordoni (D)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Antonella Fazio (A)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Georgios Marinos (G)

Institute of Experimental Medicine, University of Kiel, 24105 Kiel, Germany.

Georg Laue (G)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Simon Imm (S)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Valentina Tremaroli (V)

The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345 Gothenburg, Sweden.

Marijana Basic (M)

Institute for Laboratory Animal Science, Hannover Medical School, 30625 Hannover, Germany.

Robert Häsler (R)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

Ruth A Schmitz (RA)

Institute of General Microbiology, University of Kiel, 24118 Kiel, Germany.

Stefan Krautwald (S)

Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

Andrea Wolf (A)

Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Bärbel Stecher (B)

Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig-Maximilians-University of Munich, 80336 Munich, Germany; German Center for Infection Research (DZIF), partner site LMU Munich, Munich Germany.

Philippe Schmitt-Kopplin (P)

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, German Research Centre for Environmental Health (GmbH), 85764 Neuherberg, Germany.

Christoph Kaleta (C)

Institute of Experimental Medicine, University of Kiel, 24105 Kiel, Germany.

Jan Rupp (J)

Department of Infectious Diseases and Microbiology, University of Lübeck, 23538 Lübeck, Germany.

Fredrik Bäckhed (F)

The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345 Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.

Philip Rosenstiel (P)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany.

Felix Sommer (F)

Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany. Electronic address: f.sommer@ikmb.uni-kiel.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Cellules › Cellules épithéliales › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Hexokinase › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Microbial regulation of hexokinase 2 links...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Microbial regulation of hexokinase 2 links...