Specialized pro-resolving receptors are expressed in salivary glands with Sjögren's syndrome.
Adult
Aged, 80 and over
Female
Humans
Middle Aged
Receptors, Chemokine
/ metabolism
Receptors, Formyl Peptide
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Receptors, Leukotriene B4
/ metabolism
Receptors, Lipoxin
/ metabolism
Salivary Glands, Minor
/ metabolism
Sjogren's Syndrome
/ metabolism
Young Adult
Histology
Inflammation
Lipid mediators
Resolution
Journal
Annals of diagnostic pathology
ISSN: 1532-8198
Titre abrégé: Ann Diagn Pathol
Pays: United States
ID NLM: 9800503
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
05
10
2021
revised:
27
10
2021
accepted:
11
11
2021
pubmed:
1
12
2021
medline:
23
3
2022
entrez:
30
11
2021
Statut:
ppublish
Résumé
Our previous studies demonstrated that resolvin D1 (RvD1) and its aspirin-trigged (AT) form AT-RvD1, are effective in decreasing inflammation while restoring saliva flow rates in a Sjögren's syndrome (SS)-like mouse model before and after disease onset. Resolvins are specialized pro-resolving mediators (SPM) that actively regulate inflammation. However, we only have extensive data within the salivary glands for RvD1 and AT-RvD1, both of which bind to the receptor ALX/FPR2. As such, the presence of other SPM receptors is unknown within salivary glands. Therefore, the goal of this study was to determine the expression of SPM receptors in non-SS and SS patients. For this purpose, six human minor salivary glands from female subjects were analyzed by H&E using the Chisholm and Mason classification to determine the degree of lymphocytic infiltration. Next, confocal immunofluorescence analysis was performed to determine the presence and distribution of different SPM receptors in mucous acini and striated ducts. We observed diffuse presence of lymphocytic infiltration and clinical data were consistent with SS diagnosis in three patients. Moreover, confocal immunofluorescence analysis indicated the presence of the receptors ALX/FPR2, BLT1 and CMKLR1 in the mucous acini and striated ducts of both non-SS and SS patients. GPR32 was absent in SS and non-SS minor salivary glands. In summary, our results showed that various SPM receptors are expressed in non-SS and SS minor salivary glands, all of which may pose as potential targets for promoting pro-epithelial and anti-inflammatory/pro-resolution signaling on SS patients.
Identifiants
pubmed: 34847389
pii: S1092-9134(21)00165-9
doi: 10.1016/j.anndiagpath.2021.151865
pmc: PMC8938998
mid: NIHMS1788319
pii:
doi:
Substances chimiques
CMKLR1 protein, human
0
FPR2 protein, human
0
GPR32 protein, human
0
LTB4R protein, human
0
Receptors, Chemokine
0
Receptors, Formyl Peptide
0
Receptors, G-Protein-Coupled
0
Receptors, Leukotriene B4
0
Receptors, Lipoxin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151865Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027884
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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