Testicular macrophages: development and function in health and disease.
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
09
09
2021
revised:
02
11
2021
accepted:
02
11
2021
pubmed:
2
12
2021
medline:
8
4
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Macrophages comprise a heterogeneous immune cell population and display niche-specific phenotypes and functions in almost all organs. Testicular macrophages (TMs) perform essential immune and non-immune functions in the mammalian male gonads. Here, we discuss the most recent findings on TM ontogeny, heterogeneity, and function under steady state and inflammatory conditions. We also highlight new discoveries regarding the functions of macrophages during bacterial and viral infections of the testes and how macrophages may indirectly help the establishment of a reservoir through virus seeding. Understanding TM function and macrophage-related mechanisms of disease might assist in developing new opportunities for intervention in male infertility.
Identifiants
pubmed: 34848166
pii: S1471-4906(21)00239-8
doi: 10.1016/j.it.2021.11.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-62Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors have no conflicts of interest to declare.