Metabolites and secretory immunoglobulins: messengers and effectors of the host-microbiota intestinal equilibrium.
IgA
autoimmunity
microbiota
mucosal immunity
secretory
tolerance
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
04
09
2021
revised:
03
11
2021
accepted:
04
11
2021
pubmed:
2
12
2021
medline:
8
4
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Maintaining commensal diversity is essential to host homeostasis, because microbial species provide a range of metabolic products and continuously educate the host immune system. The mucosal immune system must actively gather information about the composition of the microbiota, while offering an appropriate response. In mammals, bacterial sensing leads to the production of specific immunoglobulins (Ig), which reach the intestinal lumen as secretory Ig (SIg). Recent work has shed more light on the mechanisms by which SIg can shape bacterial repertoires and contribute to regulating host metabolism. In parallel, bacterial metabolites modulate Ig production and secretion. Here, we present an overview of the current knowledge of the relationship between bacterial metabolites and host SIg, correlating the disruption of this balance with chronic inflammation in humans.
Identifiants
pubmed: 34848167
pii: S1471-4906(21)00241-6
doi: 10.1016/j.it.2021.11.005
pii:
doi:
Substances chimiques
Immunoglobulins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-77Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.