Understanding the role of telomere attrition and epigenetic signatures in COVID-19 severity.
COVID-19
Epigenetic
SARS-CoV-2
Severity
Telomere
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
15 Feb 2022
15 Feb 2022
Historique:
received:
05
07
2021
revised:
12
10
2021
accepted:
16
11
2021
pubmed:
2
12
2021
medline:
7
1
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Within the past several decades, the emergence and spread of infectious diseases with pandemic potential have endangered human lives. Coronavirus disease 2019 (COVID-19) outbreak represents an unprecedented threat for all health systems worldwide. The clinical spectrum of COVID-19 is highly heterogeneous, ranging from asymptomatic and mild upper respiratory tract illness to severe interstitial pneumonia with respiratory failure and even death. Highly age-dependent patterns of immune response potentially explain the higher rates of the severe forms of COVID-19 in elderly patients. However, genetic and epigenetic architecture can influence multiple biological processes during the lifespan, therefore as far as our knowledge shows, vulnerability to viral infection concerning telomere length and epigenetic signature is not a new idea. This review aims is to summarize the current understanding of the role of telomere length and epigenetic mechanisms on the severity of COVID-19. The current knowledge highlights the significant association between the shorter telomere length and the higher risk of developing severe COVID-19. Differential DNA methylation patterns and miRNA expression profiles imply that these hallmarks can play a pivotal role in COVID- 19 pathogenesis. Understanding the causes of inter-individual variations in COVID-19 outcomes could provide clues to the development of the personalized therapeutic intervention.
Identifiants
pubmed: 34848322
pii: S0378-1119(21)00664-8
doi: 10.1016/j.gene.2021.146069
pmc: PMC8634871
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
146069Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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