GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival.
Aldehyde Dehydrogenase 1 Family
/ genetics
Biomarkers, Tumor
Breast Neoplasms
/ etiology
Cell Line, Tumor
Cell Survival
Female
Flow Cytometry
Gene Expression Profiling
Humans
Isoenzymes
/ metabolism
Lactoylglutathione Lyase
/ metabolism
Neoplasm Staging
Neoplastic Stem Cells
/ metabolism
Protein Kinase C
/ metabolism
Transcriptome
ALDH1A3
Cancer stem cell
GLO 1
PKCλ
breast cancer
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
11
09
2021
revised:
30
09
2021
accepted:
01
10
2021
entrez:
1
12
2021
pubmed:
2
12
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
We examined the inhibitory effects of both glyoxalase 1 (GLO 1) and protein kinase C (PKC)λ in aldehyde dehydrogenase 1 (ALDH1)-positive breast cancer stem cells (CSCs). Breast cancer genomics datasets (TCGA, n=593; METABRIC, n=1904) were downloaded and statistically analyzed. The effects of GLO 1 and PKCλ on trypan blue staining and tumor-sphere formation by ALDH1 GLO 1 GLO 1 and PKCλ are important for the survival of ALDH1-positive breast CSCs, and may represent potential therapeutic targets for the treatment of ALDH1-positive breast CSCs.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
We examined the inhibitory effects of both glyoxalase 1 (GLO 1) and protein kinase C (PKC)λ in aldehyde dehydrogenase 1 (ALDH1)-positive breast cancer stem cells (CSCs).
MATERIALS AND METHODS
METHODS
Breast cancer genomics datasets (TCGA, n=593; METABRIC, n=1904) were downloaded and statistically analyzed. The effects of GLO 1 and PKCλ on trypan blue staining and tumor-sphere formation by ALDH1
RESULTS
RESULTS
GLO 1
CONCLUSION
CONCLUSIONS
GLO 1 and PKCλ are important for the survival of ALDH1-positive breast CSCs, and may represent potential therapeutic targets for the treatment of ALDH1-positive breast CSCs.
Identifiants
pubmed: 34848450
pii: 41/12/5959
doi: 10.21873/anticanres.15415
doi:
Substances chimiques
Biomarkers, Tumor
0
Isoenzymes
0
Aldehyde Dehydrogenase 1 Family
EC 1.2.1
Protein Kinase C
EC 2.7.11.13
protein kinase C lambda
EC 2.7.11.13
GLO1 protein, human
EC 4.4.1.5
Lactoylglutathione Lyase
EC 4.4.1.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5959-5971Informations de copyright
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.