Preservation of Eye Movements in Parkinson's Disease Is Stimulus- and Task-Specific.
Parkinson's disease
eye movements
prediction
preservation of function
saccades
smooth pursuit
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
19 01 2022
19 01 2022
Historique:
received:
19
08
2021
revised:
09
11
2021
accepted:
11
11
2021
pubmed:
2
12
2021
medline:
17
2
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a neurodegenerative disease that includes motor impairments, such as tremor, bradykinesia, and postural instability. Although eye movement deficits are commonly found in saccade and pursuit tasks, preservation of oculomotor function has also been reported. Here we investigate specific task and stimulus conditions under which oculomotor function in PD is preserved. Sixteen PD patients and 18 healthy, age-matched controls completed a battery of movement tasks that included stationary or moving targets eliciting reactive or deliberate eye movements: pro-saccades, anti-saccades, visually guided pursuit, and rapid go/no-go manual interception. Compared with controls, patients demonstrated systematic impairments in tasks with stationary targets: pro-saccades were hypometric and anti-saccades were incorrectly initiated toward the cued target in ∼35% of trials compared with 14% errors in controls. In patients, task errors were linked to short latency saccades, indicating abnormalities in inhibitory control. However, patients' eye movements in response to dynamic targets were relatively preserved. PD patients were able to track and predict a disappearing moving target and make quick go/no-go decisions as accurately as controls. Patients' interceptive hand movements were slower on average but initiated earlier, indicating adaptive processes to compensate for motor slowing. We conclude that PD patients demonstrate stimulus and task dependency of oculomotor impairments, and we propose that preservation of eye and hand movement function in PD is linked to a separate functional pathway through the superior colliculus-brainstem loop that bypasses the fronto-basal ganglia network. Our results demonstrate that studying oculomotor and hand movement function in PD can support disease diagnosis and further our understanding of disease progression and dynamics.
Identifiants
pubmed: 34848498
pii: JNEUROSCI.1690-21.2021
doi: 10.1523/JNEUROSCI.1690-21.2021
pmc: PMC8802919
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
487-499Informations de copyright
Copyright © 2022 the authors.
Références
Trends Neurosci. 1989 Oct;12(10):366-75
pubmed: 2479133
Mov Disord. 2019 Nov;34(11):1690-1698
pubmed: 31442355
Annu Rev Neurosci. 2007;30:259-88
pubmed: 17600522
Nat Neurosci. 2008 Jan;11(1):103-7
pubmed: 18066057
Mov Disord. 2007 Jul 30;22(10):1444-1450
pubmed: 17516454
J Exp Psychol Hum Percept Perform. 1982 Feb;8(1):113-26
pubmed: 6460077
J Neurophysiol. 2020 Apr 1;123(4):1439-1447
pubmed: 32159423
PLoS One. 2018 Nov 28;13(11):e0207589
pubmed: 30485332
Eur J Neurosci. 2005 Jul;22(2):448-64
pubmed: 16045498
Trends Neurosci. 1991 Nov;14(11):480-2
pubmed: 1726761
Neuropsychologia. 2005;43(5):784-96
pubmed: 15721191
Nat Rev Neurosci. 2004 Mar;5(3):218-28
pubmed: 14976521
Physiol Rep. 2015 Mar;3(3):
pubmed: 25825544
Prog Brain Res. 2019;249:297-305
pubmed: 31325988
J Neurosci. 2013 Jun 12;33(24):9985-97
pubmed: 23761894
J Vis. 2019 Feb 1;19(2):5
pubmed: 30735563
Psychophysiology. 2006 May;43(3):302-13
pubmed: 16805870
J Neurosci. 2007 Oct 31;27(44):11860-4
pubmed: 17978025
Mov Disord. 2021 May;36(5):1115-1118
pubmed: 33656203
Vision Res. 2021 Nov;188:283-296
pubmed: 34489101
Front Behav Neurosci. 2012 Dec 13;6:88
pubmed: 23248593
Brain. 2004 Aug;127(Pt 8):1755-73
pubmed: 15215215
PLoS One. 2013 Nov 06;8(11):e78581
pubmed: 24223158
Neurosci Res. 2002 Jun;43(2):111-7
pubmed: 12067746
J Neurosci. 2008 Nov 19;28(47):12294-304
pubmed: 19020023
Prog Neurobiol. 2013 Sep;108:44-79
pubmed: 23856628
Neuropsychologia. 2006;44(8):1475-82
pubmed: 16376954
Trends Neurosci. 2018 Aug;41(8):512-525
pubmed: 29747856
Neuropsychologia. 2013 Jan;51(2):340-8
pubmed: 23063965
Neuropsychologia. 2016 Jan 8;80:102-114
pubmed: 26529488
Neuron. 2017 Aug 30;95(5):1160-1170.e5
pubmed: 28823728
Exp Brain Res. 1999 Nov;129(1):38-48
pubmed: 10550501
Trends Neurosci. 2014 Sep;37(9):467-9
pubmed: 25131358
Prog Brain Res. 2010;183:275-97
pubmed: 20696325
Trends Neurosci. 1990 Jul;13(7):266-71
pubmed: 1695401
Neuropsychologia. 2011 Jun;49(7):1794-806
pubmed: 21420990
J Parkinsons Dis. 2015;5(4):715-26
pubmed: 26599301
Neuropsychol Rev. 2021 Dec;31(4):628-642
pubmed: 33742354
Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5696-5704
pubmed: 27784075
eNeuro. 2017 Oct 16;4(5):
pubmed: 29085900
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Spat Vis. 1997;10(4):437-42
pubmed: 9176953
Clin Exp Optom. 2008 Mar;91(2):129-38
pubmed: 18271776
Brain. 2021 Mar 3;144(2):504-514
pubmed: 33279957
Vision Res. 2008 May;48(10):1254-61
pubmed: 18396307
Neural Netw. 2004 May;17(4):471-510
pubmed: 15109680
Parkinsonism Relat Disord. 2019 Nov;68:49-56
pubmed: 31621619
Rev Physiol Biochem Pharmacol. 1987;106:1-35
pubmed: 3112911
Curr Biol. 2016 Jul 25;26(14):1902-10
pubmed: 27322000
Psychopharmacology (Berl). 2007 Apr;191(3):507-20
pubmed: 17031711
J Neurosci. 2008 Mar 19;28(12):3008-16
pubmed: 18354004
Ann Neurol. 1996 Mar;39(3):368-77
pubmed: 8602756
Prog Neurobiol. 1996 Nov;50(4):381-425
pubmed: 9004351
Physiol Rev. 2000 Jul;80(3):953-78
pubmed: 10893428
J Neurosci. 2007 Jul 4;27(27):7105-16
pubmed: 17611263
Curr Opin Neurol. 2016 Feb;29(1):69-73
pubmed: 26641812
J Parkinsons Dis. 2019;9(3):625-630
pubmed: 31282422
Brain. 1998 Apr;121 ( Pt 4):755-66
pubmed: 9577399
Exp Brain Res. 2017 May;235(5):1309-1321
pubmed: 28258438
Exp Neurol. 2008 Apr;210(2):479-88
pubmed: 18237731
J Vis. 2011 Sep 14;11(5):
pubmed: 21917784
Science. 2004 Dec 10;306(5703):1940-3
pubmed: 15528409
Neuron. 2014 Jun 18;82(6):1230-43
pubmed: 24945769
J Neurol. 2008 Jul;255(7):1071-8
pubmed: 18438696
Spat Vis. 1997;10(4):433-6
pubmed: 9176952
Mov Disord. 2015 May;30(6):843-7
pubmed: 25600361
Eur J Neurosci. 2021 Apr;53(8):2713-2725
pubmed: 33450082
Brain Cogn. 2008 Dec;68(3):415-35
pubmed: 19028266
J Neurosci. 2016 Aug 3;36(31):8273-82
pubmed: 27488645
Neurology. 2018 Jul 17;91(3):e189-e201
pubmed: 29925549
Neuroimage. 2012 Apr 2;60(2):1156-70
pubmed: 22270353
Trends Neurosci. 2015 Apr;38(4):247-58
pubmed: 25765322
Mov Disord. 2004 Sep;19(9):1020-8
pubmed: 15372591
J Vis. 2019 Aug 1;19(9):10
pubmed: 31434106
Mov Disord. 2012 Jul;27(8):1012-8
pubmed: 22693071
J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):565-70
pubmed: 17178817
Neuropsychologia. 1998 Sep;36(9):885-99
pubmed: 9740362
Trends Neurosci. 2011 Dec;34(12):611-8
pubmed: 22018805
Front Hum Neurosci. 2019 Apr 03;13:118
pubmed: 31001099