Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK).

COVID-19 / epidemiology Cohort Studies Humans Longitudinal Studies Male Prospective Studies Risk Factors SARS-CoV-2 United Kingdom / epidemiology

COVID-19 allergic lung disease asthma epidemiology clinical epidemiology

Journal

Thorax

ISSN: 1468-3296

Titre abrégé: Thorax

Pays: England

ID NLM: 0417353

Informations de publication

Date de publication:
09 2022

Historique:

received: 19 04 2021

accepted: 09 09 2021

pubmed: 2 12 2021

medline: 20 8 2022

entrez: 1 12 2021

Statut: ppublish

Résumé

Risk factors for severe COVID-19 include older age, male sex, obesity, black or Asian ethnicity and underlying medical conditions. Whether these factors also influence susceptibility to developing COVID-19 is uncertain. We undertook a prospective, population-based cohort study (COVIDENCE UK) from 1 May 2020 to 5 February 2021. Baseline information on potential risk factors was captured by an online questionnaire. Monthly follow-up questionnaires captured incident COVID-19. We used logistic regression models to estimate multivariable-adjusted ORs (aORs) for associations between potential risk factors and odds of COVID-19. We recorded 446 incident cases of COVID-19 in 15 227 participants (2.9%). Increased odds of developing COVID-19 were independently associated with Asian/Asian British versus white ethnicity (aOR 2.28, 95% CI 1.33 to 3.91), household overcrowding (aOR per additional 0.5 people/bedroom 1.26, 1.11 to 1.43), any versus no visits to/from other households in previous week (aOR 1.31, 1.06 to 1.62), number of visits to indoor public places (aOR per extra visit per week 1.05, 1.02 to 1.09), frontline occupation excluding health/social care versus no frontline occupation (aOR 1.49, 1.12 to 1.98) and raised body mass index (BMI) (aOR 1.50 (1.19 to 1.89) for BMI 25.0-30.0 kg/m After rigorous adjustment for factors influencing exposure to SARS-CoV-2, Asian/Asian British ethnicity and raised BMI were associated with increased odds of developing COVID-19, while atopic disease was associated with decreased odds. ClinicalTrials.gov Registry (NCT04330599).

Sections du résumé

BACKGROUND

METHODS

We undertook a prospective, population-based cohort study (COVIDENCE UK) from 1 May 2020 to 5 February 2021. Baseline information on potential risk factors was captured by an online questionnaire. Monthly follow-up questionnaires captured incident COVID-19. We used logistic regression models to estimate multivariable-adjusted ORs (aORs) for associations between potential risk factors and odds of COVID-19.

RESULTS

We recorded 446 incident cases of COVID-19 in 15 227 participants (2.9%). Increased odds of developing COVID-19 were independently associated with Asian/Asian British versus white ethnicity (aOR 2.28, 95% CI 1.33 to 3.91), household overcrowding (aOR per additional 0.5 people/bedroom 1.26, 1.11 to 1.43), any versus no visits to/from other households in previous week (aOR 1.31, 1.06 to 1.62), number of visits to indoor public places (aOR per extra visit per week 1.05, 1.02 to 1.09), frontline occupation excluding health/social care versus no frontline occupation (aOR 1.49, 1.12 to 1.98) and raised body mass index (BMI) (aOR 1.50 (1.19 to 1.89) for BMI 25.0-30.0 kg/m

CONCLUSIONS

After rigorous adjustment for factors influencing exposure to SARS-CoV-2, Asian/Asian British ethnicity and raised BMI were associated with increased odds of developing COVID-19, while atopic disease was associated with decreased odds.

TRIAL REGISTRATION NUMBER

ClinicalTrials.gov Registry (NCT04330599).

Identifiants

DOI: 10.1136/thoraxjnl-2021-217487 PMID: 34848555

pubmed: 34848555

pii: thoraxjnl-2021-217487

doi: 10.1136/thoraxjnl-2021-217487

doi:

Banques de données

ClinicalTrials.gov

['NCT04330599']

Types de publication

Clinical Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng