Structure network-based landscape of rhodopsin misfolding by mutations and algorithmic prediction of small chaperone action.
Conformational diseases
GPCRs
Molecular simulations
Pharmacological chaperones
Protein structure network
Rhodopsin
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
08
2021
revised:
09
10
2021
accepted:
31
10
2021
entrez:
1
12
2021
pubmed:
2
12
2021
medline:
2
12
2021
Statut:
epublish
Résumé
Failure of a protein to achieve its functional structural state and normal cellular location contributes to the etiology and pathology of heritable human conformational diseases. The autosomal dominant form of retinitis pigmentosa (adRP) is an incurable blindness largely linked to mutations of the membrane protein rod opsin. While the mechanisms underlying the noxious effects of the mutated protein are not completely understood, a common feature is the functional protein conformational loss. Here, the wild type and 39 adRP rod opsin mutants were subjected to mechanical unfolding simulations coupled to the graph theory-based protein structure network analysis. A robust computational model was inferred and
Identifiants
pubmed: 34849206
doi: 10.1016/j.csbj.2021.10.040
pii: S2001-0370(21)00462-1
pmc: PMC8605067
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6020-6038Informations de copyright
© 2021 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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