Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients.
Multispectral optoacoustic tomography
Optoacoustics
Photoacoustics
Spinal muscular atrophie
Journal
Photoacoustics
ISSN: 2213-5979
Titre abrégé: Photoacoustics
Pays: Germany
ID NLM: 101622604
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
28
04
2021
revised:
02
11
2021
accepted:
08
11
2021
entrez:
1
12
2021
pubmed:
2
12
2021
medline:
2
12
2021
Statut:
epublish
Résumé
Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. We demonstrate handheld Multispectral Optoacoustic Tomography (MSOT) as a novel non-invasive imaging approach to visualize and quantify muscle wasting in pediatric SMA. While MSOT signals were distributed homogeneously in muscles of healthy volunteers (HVs), SMA patients showed moth-eaten optoacoustic signal patterns. Further signal quantification revealed greatest differences between groups at the isosbestic point for hemoglobin (SWL 800 nm). The SWL 800 nm signal intensities further correlated with clinical phenotype tested by standard motor outcome measures. Therefore, handheld MSOT could enable non-invasive assessment of disease burden in SMA patients.
Identifiants
pubmed: 34849338
doi: 10.1016/j.pacs.2021.100315
pii: S2213-5979(21)00074-4
pmc: PMC8607197
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100315Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: A.P.R., M.J.W., F.K. are co-inventors together with iThera Medical GmbH, Germany on an EU patent application (EP 19 163 304.9) relating to a device and a method for analyzing optoacoustic data, an optoacoustic system and a computer program. A.P.R., M.J.W., and F.K. received travel support by iThera Medical GmbH, Germany. A.P.R. reports lecture fees from Sanofi Genzyme. F.K. reports lecture fees from Siemens Healthcare GmbH outside the submitted work. All other authors declare no competing interests. F.K. is an editor of the Journal (“Photoacoustics”).
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