DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
accepted:
20
10
2021
revised:
15
10
2021
received:
15
09
2021
pubmed:
2
12
2021
medline:
24
2
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
Identifiants
pubmed: 34850135
pii: 6439667
doi: 10.1093/nar/gkab1082
pmc: PMC8728214
doi:
Substances chimiques
Intrinsically Disordered Proteins
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
D480-D487Subventions
Organisme : NHGRI NIH HHS
ID : U24 HG012212
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG002273
Pays : United States
Organisme : Cancer Research UK
ID : C68484/A28159
Pays : United Kingdom
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
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