Testing Black-White Disparities in Biological Aging Among Older Adults in the United States: Analysis of DNA-Methylation and Blood-Chemistry Methods.
aging
aging clocks
biological aging
healthy aging
pace of aging
racial disparities
Journal
American journal of epidemiology
ISSN: 1476-6256
Titre abrégé: Am J Epidemiol
Pays: United States
ID NLM: 7910653
Informations de publication
Date de publication:
24 03 2022
24 03 2022
Historique:
received:
01
03
2021
revised:
30
10
2021
accepted:
23
11
2021
pubmed:
2
12
2021
medline:
5
4
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Biological aging is a proposed mechanism through which social determinants drive health disparities. We conducted proof-of-concept testing of 8 DNA-methylation (DNAm) and blood-chemistry quantifications of biological aging as mediators of disparities in healthspan between Black and White participants in the 2016 wave of the Health and Retirement Study (n = 9,005). We quantified biological aging from 4 DNAm "clocks" (Horvath, Hannum, PhenoAge, and GrimAge clock), a DNAm pace-of-aging measure (DunedinPoAm), and 3 blood-chemistry measures (PhenoAge, Klemera-Doubal method biological age, and homeostatic dysregulation). We quantified Black-White disparities in healthspan from cross-sectional and longitudinal data on physical performance tests, self-reported limitations in activities of daily living, and physician-diagnosed chronic diseases, self-rated health, and survival. DNAm and blood-chemistry quantifications of biological aging were moderately correlated (Pearson's r = 0.1-0.4). The GrimAge clock, DunedinPoAm, and all 3 blood-chemistry measures were associated with healthspan characteristics (e.g., mortality effect-size hazard ratios were 1.71-2.32 per standard deviation of biological aging) and showed evidence of more advanced/faster biological aging in Black participants than in White participants (Cohen's d = 0.4-0.5). These measures accounted for 13%-95% of Black-White differences in healthspan-related characteristics. Findings suggest that reducing disparities in biological aging can contribute to building health equity.
Identifiants
pubmed: 34850809
pii: 6446894
doi: 10.1093/aje/kwab281
pmc: PMC9077113
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
613-625Subventions
Organisme : NIA NIH HHS
ID : R01 AG061378
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066887
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Stat Med. 2014 Dec 10;33(28):4875-90
pubmed: 25220625
EBioMedicine. 2017 Jul;21:29-36
pubmed: 28396265
Ethn Dis. 1992 Summer;2(3):207-21
pubmed: 1467758
Geroscience. 2018 Dec;40(5-6):419-436
pubmed: 30151729
N Engl J Med. 2020 Jul 16;383(3):201-203
pubmed: 32374952
Am J Public Health. 2019 Jan;109(S1):S72-S78
pubmed: 30699019
J Gerontol A Biol Sci Med Sci. 2021 May 22;76(6):1117-1123
pubmed: 33453106
J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):463-465
pubmed: 31995162
Am J Public Health. 2006 May;96(5):826-33
pubmed: 16380565
Aging (Albany NY). 2019 Jan 21;11(2):303-327
pubmed: 30669119
Annu Rev Public Health. 2008;29:235-52
pubmed: 18031225
Am J Public Health. 2019 Jan;109(S1):S86-S93
pubmed: 30699029
Am J Public Health. 2019 Jan;109(S1):S56-S63
pubmed: 30699032
JAMA. 2018 Oct 2;320(13):1321-1322
pubmed: 30242337
Elife. 2021 Feb 09;10:
pubmed: 33558008
Geroscience. 2021 Dec;43(6):2795-2808
pubmed: 34725754
Am J Epidemiol. 2018 Jun 1;187(6):1220-1230
pubmed: 29149257
Health Aff (Millwood). 2009 Jan-Feb;28(1):160-8
pubmed: 19124866
Mech Ageing Dev. 2006 Mar;127(3):240-8
pubmed: 16318865
PLoS Med. 2019 Jun 18;16(6):e1002827
pubmed: 31211779
Nat Rev Genet. 2013 Aug;14(8):585-94
pubmed: 23817309
Psychol Methods. 2013 Jun;18(2):137-50
pubmed: 23379553
Aging Cell. 2020 Feb;19(2):e13080
pubmed: 31833194
Soc Sci Med. 2014 Oct;118:27-32
pubmed: 25086423
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Pediatrics. 2009 Nov;124 Suppl 3:S163-75
pubmed: 19861467
Health Aff (Millwood). 2016 Aug 1;35(8):1429-34
pubmed: 27503968
J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):210-215
pubmed: 28087676
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
Am J Public Health. 2019 Jan;109(S1):S48-S55
pubmed: 30699022
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
SSM Popul Health. 2019 May 28;8:100417
pubmed: 31193960
Health Aff (Millwood). 2018 Mar;37(3):371-377
pubmed: 29505363
J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):1671-1679
pubmed: 31693736
Elife. 2020 Feb 11;9:
pubmed: 32041686
Genome Biol. 2016 Aug 11;17(1):171
pubmed: 27511193
Psychoneuroendocrinology. 2019 Jun;104:18-24
pubmed: 30784901
J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):4-10
pubmed: 28531269
J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):99-101
pubmed: 31834386
Cell. 2005 Feb 25;120(4):437-47
pubmed: 15734677
Elife. 2020 May 05;9:
pubmed: 32367804
Mech Ageing Dev. 2020 Oct;191:111316
pubmed: 32693105
J Health Soc Behav. 2010;51 Suppl:S28-40
pubmed: 20943581
Ann Epidemiol. 2019 Jan;29:1-7
pubmed: 30342887
Mech Ageing Dev. 2013 Mar;134(3-4):110-7
pubmed: 23376244
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Epidemiology. 2021 Sep 1;32(5):e20-e22
pubmed: 34028370
Aging (Albany NY). 2019 Apr 14;11(7):2045-2070
pubmed: 31009935
Natl Vital Stat Rep. 2019 May;68(4):1-66
pubmed: 31112121
Nature. 2018 Feb;554(7692):293-295
pubmed: 32094723
Health Aff (Millwood). 2016 Aug 1;35(8):1416-23
pubmed: 27503966
Elife. 2020 Jun 09;9:
pubmed: 32515735