Stem cell therapy in the treatment of organic and dysfunctional endometrial pathology.


Journal

Minerva obstetrics and gynecology
ISSN: 2724-6450
Titre abrégé: Minerva Obstet Gynecol
Pays: Italy
ID NLM: 101777346

Informations de publication

Date de publication:
Dec 2022
Historique:
pubmed: 2 12 2021
medline: 20 12 2022
entrez: 1 12 2021
Statut: ppublish

Résumé

Intrauterine adhesions caused by postpartum curettage, spontaneous abortions, interrupted pregnancies, endometrial ablations, infections and inflammations, can lead to a loss of endometrial function, with consequent hypomenorrhea and infertility in women of reproductive age. In a non-negligible percentage of cases, the available surgical methods and hormone therapy, with sequential administration of estrogen and progesterone, are ineffective. In fact, severe damage to the basal layer of the endometrium causes the loss of endometrial cell precursors and leads to the failure of regeneration of the functional layer to which the endometrium is cyclically exposed. Today, many researchers are evaluating the use of stem cells of different origins as a potential therapy to restore endometrial function. Our interest has been focused on adipose-derived stromal/stem cells (ADSCs) obtained by collecting subcutaneous adipose tissue and subsequently treating it with the MilliGraft The data obtained, even though they still require further support and implementation, show the regenerative properties of SVF obtained from adipose tissue using a mechanical method. These findings can contribute to the development of cell therapies using stem cells of different derivations which are increasingly being utilized in the treatment of endometrial lesions from adherent or dysfunctional pathologies.

Sections du résumé

BACKGROUND BACKGROUND
Intrauterine adhesions caused by postpartum curettage, spontaneous abortions, interrupted pregnancies, endometrial ablations, infections and inflammations, can lead to a loss of endometrial function, with consequent hypomenorrhea and infertility in women of reproductive age. In a non-negligible percentage of cases, the available surgical methods and hormone therapy, with sequential administration of estrogen and progesterone, are ineffective. In fact, severe damage to the basal layer of the endometrium causes the loss of endometrial cell precursors and leads to the failure of regeneration of the functional layer to which the endometrium is cyclically exposed. Today, many researchers are evaluating the use of stem cells of different origins as a potential therapy to restore endometrial function.
METHODS METHODS
Our interest has been focused on adipose-derived stromal/stem cells (ADSCs) obtained by collecting subcutaneous adipose tissue and subsequently treating it with the MilliGraft
RESULTS RESULTS
The data obtained, even though they still require further support and implementation, show the regenerative properties of SVF obtained from adipose tissue using a mechanical method.
CONCLUSIONS CONCLUSIONS
These findings can contribute to the development of cell therapies using stem cells of different derivations which are increasingly being utilized in the treatment of endometrial lesions from adherent or dysfunctional pathologies.

Identifiants

pubmed: 34851073
pii: S2724-606X.21.04919-8
doi: 10.23736/S2724-606X.21.04919-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

504-515

Auteurs

Ettore Cittadini (E)

Fondazione per gli Studi sulla Riproduzione Umana, Clinica Candela, Palermo, Italy - info@ettorecittadini.it.

Anna M Brucculeri (AM)

Fondazione per gli Studi sulla Riproduzione Umana, Clinica Candela, Palermo, Italy.

Fabrizio Quartararo (F)

Fondazione per gli Studi sulla Riproduzione Umana, Clinica Candela, Palermo, Italy.

Roberto Vaglica (R)

Fondazione per gli Studi sulla Riproduzione Umana, Clinica Candela, Palermo, Italy.

Vitale Miceli (V)

IRCCS ISMETT Research Department, Palermo, Italy.

Pier G Conaldi (PG)

IRCCS ISMETT Research Department, Palermo, Italy.

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Classifications MeSH