Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced Immunity.
Adult
Aged
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ blood
BNT162 Vaccine
/ immunology
COVID-19
/ immunology
Cross Reactions
Female
Humans
Immunity
Immunity, Humoral
Male
Middle Aged
Neutralization Tests
SARS-CoV-2
/ classification
Spike Glycoprotein, Coronavirus
Vaccination
Viral Pseudotyping
Young Adult
mRNA Vaccines
/ immunology
BNT162b2
SARS-CoV-2
neutralizing antibodies
receptor-binding domain
variants
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
22 12 2021
22 12 2021
Historique:
pubmed:
2
12
2021
medline:
6
1
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Vaccines against severe acute respiratory syndrome coronavirus-2 have been introduced. To investigate the relationship between vaccine-induced humoral immunity and patient age, we measured antibody levels and neutralization in vaccinated sera. Sera from 13 to 17 days after the second dose of the BNT162b2 vaccine were collected from health care workers at the University of Toyama (
Identifiants
pubmed: 34851162
doi: 10.1128/Spectrum.00561-21
pmc: PMC8635122
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Spike Glycoprotein, Coronavirus
0
mRNA Vaccines
0
spike protein, SARS-CoV-2
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0056121Subventions
Organisme : University of Toyama ()
ID : The Research Funding Grant by the president
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20he0622035
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