Response to comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics".

Cardiovascular Diseases / genetics Human Genetics Humans

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
12 2021
Historique:
entrez: 1 12 2021
pubmed: 2 12 2021
medline: 1 4 2022
Statut: ppublish

Résumé

Triangulation of evidence from clinical trials and human genetics suggests a potential excess risk of cardiovascular disease events arising from therapeutic inhibition of sclerostin.

Identifiants

DOI: 10.1126/scitranslmed.abf4530 PMID: 34851696
pubmed: 34851696
doi: 10.1126/scitranslmed.abf4530
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabf4530

Subventions

Organisme : British Heart Foundation
ID : FS/18/23/33512
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202922/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00017/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/1/30181
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : P50 HD028138
Pays : United States
Organisme : Wellcome Trust
ID : 104085/Z/14/Z
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14135
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13049
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 088158/Z/09/Z
Pays : United Kingdom

Commentaires et corrections

Type : CommentOn
Type : CommentOn

Auteurs

Jonas Bovijn (J)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
ORCID: 0000-0001-7436-4446

Kristi Krebs (K)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
ORCID: 0000-0003-0494-2751

Chia-Yen Chen (CY)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
ORCID: 0000-0001-9548-5597

Ruth Boxall (R)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
ORCID: 0000-0003-0356-3549

Jenny C Censin (JC)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
ORCID: 0000-0001-6625-6074

Teresa Ferreira (T)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0002-4333-1390

Sara L Pulit (SL)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
Department of Genetics, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.
ORCID: 0000-0002-2502-3669

Craig A Glastonbury (CA)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0001-5542-2225

Samantha Laber (S)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

Iona Y Millwood (IY)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Kuang Lin (K)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Liming Li (L)

Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing 100191, China.
ORCID: 0000-0001-5873-7089

Zhengming Chen (Z)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Lili Milani (L)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
ORCID: 0000-0002-5323-3102

George Davey Smith (GD)

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol BS8 2BN, UK.
ORCID: 0000-0002-1407-8314

Robin G Walters (RG)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
ORCID: 0000-0002-9179-0321

Reedik Mägi (R)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
ORCID: 0000-0002-2964-6011

Benjamin M Neale (BM)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
ORCID: 0000-0003-1513-6077

Cecilia M Lindgren (CM)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.
ORCID: 0000-0002-4903-9374

Michael V Holmes (MV)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.
ORCID: 0000-0001-6617-0879

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Response to comment on "Evaluating the...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génétique humaine › Response to comment on "Evaluating the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Response to comment on "Evaluating the...