Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test.
Adult
Analgesics, Opioid
/ administration & dosage
Blood Pressure
/ drug effects
Cardiovascular System
/ innervation
Cold Temperature
Cross-Over Studies
Female
Fentanyl
/ administration & dosage
Humans
Immersion
Male
Muscle, Skeletal
/ innervation
Pain
/ drug therapy
Pain Perception
/ drug effects
Pain Threshold
/ drug effects
Sympathetic Nervous System
/ drug effects
Time Factors
Water
Young Adult
algometry
cerebral tissue oxygenation
opioids
respiration
sympathoexcitatory
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
pubmed:
2
12
2021
medline:
15
2
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
Our knowledge about how low-dose (analgesic) fentanyl affects autonomic cardiovascular regulation is primarily limited to animal experiments. Notably, it is unknown if low-dose fentanyl influences human autonomic cardiovascular responses during painful stimuli in humans. Therefore, we tested the hypothesis that low-dose fentanyl reduces perceived pain and subsequent sympathetic and cardiovascular responses in humans during an experimental noxious stimulus. Twenty-three adults (10 females/13 males; 27 ± 7 yr; 26 ± 3 kg·m
Identifiants
pubmed: 34851729
doi: 10.1152/ajpregu.00218.2021
pmc: PMC8742733
doi:
Substances chimiques
Analgesics, Opioid
0
Water
059QF0KO0R
Fentanyl
UF599785JZ
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
R64-R76Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL154559
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL154565
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL154189
Pays : United States
Commentaires et corrections
Type : ErratumIn
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