Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2.
RBL2/p130
SCF
cancer biology
cell biology
cell cycle
cyclin F
human
retinoblastoma
ubiquitin
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
received:
26
05
2021
accepted:
19
11
2021
pubmed:
2
12
2021
medline:
27
1
2022
entrez:
1
12
2021
Statut:
epublish
Résumé
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation, and suppressing tumorigenesis. Phosphorylation of RB-family proteins by cyclin-dependent kinases is firmly established. Like phosphorylation, ubiquitination is essential to cell cycle control, and numerous proliferative regulators, tumor suppressors, and oncoproteins are ubiquitinated. However, little is known about the role of ubiquitin signaling in controlling RB-family proteins. A systems genetics analysis of CRISPR/Cas9 screens suggested the potential regulation of the RB-network by cyclin F, a substrate recognition receptor for the SCF family of E3 ligases. We demonstrate that RBL2/p130 is a direct substrate of SCF
Identifiants
pubmed: 34851822
doi: 10.7554/eLife.70691
pii: 70691
pmc: PMC8670743
doi:
pii:
Substances chimiques
CCNF protein, human
0
Cyclins
0
KITLG protein, human
0
RBL2 protein, human
0
Retinoblastoma-Like Protein p130
0
Stem Cell Factor
0
Banques de données
Dryad
['10.5061/dryad.69p8cz93d']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007040
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120309
Pays : United States
Organisme : NICHD NIH HHS
ID : DP2 HD091800
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163834
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128855
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM138834
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127707
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM134231
Pays : United States
Informations de copyright
© 2021, Enrico et al.
Déclaration de conflit d'intérêts
TE, WS, EW, PN, XW, SR, NB, JP, ME No competing interests declared
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