Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor therapy application.
Aqueous electrospinning
Curcumin
Curcuminoids
Cyclodextrin
Fast-dissolving
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
05 Jan 2022
05 Jan 2022
Historique:
received:
16
07
2021
revised:
24
11
2021
accepted:
25
11
2021
pubmed:
2
12
2021
medline:
24
12
2021
entrez:
1
12
2021
Statut:
ppublish
Résumé
Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclodextin (HP-β-CD). In the electrospinning process HP-β-CD could act both as solubilizer and fiber-forming agent. The solubilization efficiency of the CU-HP-β-CD systems was determined with phase-solubility measurements. The electrospun CUs were amorphous and uniformly distributed in the fibers according to XRD analysis and Raman mappings. The fibrous final products had fast (<5 min) and complete dissolution. In typical iv. infusion reconstitution volume (20 mL) fibers containing 40-80 mg of CU could be dissolved, which is similar to the currently proposed dose (<120 mg/m
Identifiants
pubmed: 34852289
pii: S0378-5173(21)01133-9
doi: 10.1016/j.ijpharm.2021.121327
pii:
doi:
Substances chimiques
Diarylheptanoids
0
Excipients
0
Hypromellose Derivatives
3NXW29V3WO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121327Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.