Exopolysaccharide Produced by Plant-Derived Lactobacillus plantarum SN35N Exhibits Antiviral Activity.


Journal

Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984

Informations de publication

Date de publication:
2021
Historique:
entrez: 2 12 2021
pubmed: 3 12 2021
medline: 1 2 2022
Statut: ppublish

Résumé

A lactic acid bacterial strain, Lactobacillus plantarum SN35N, which has been isolated from the pear, secretes negatively charged acidic exopolysaccharide (EPS) to outside cells. We have previously found that the SN35N-derived acidic EPS inhibits the catalytic activity of hyaluronidase (EC 3.2.1.35) promoting inflammation. The aim of this study is to find other health benefits of EPS. EPS has been found to exhibit an inhibitory effect against the influenza virus (Alphainfluenzavirus Influenza A virus) and feline calicivirus (Vesivirus Feline calicivirus), which is recognized as a model of norovirus. Although more studies on the structure-function relationship of EPSs are needed, SN35N-derived EPS is a promising lead for developing not only anti-inflammatory agents, but also antiviral substances.

Identifiants

pubmed: 34853272
doi: 10.1248/bpb.b21-00517
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Antiviral Agents 0
Polysaccharides, Bacterial 0
Hyaluronoglucosaminidase EC 3.2.1.35

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1886-1890

Auteurs

Masafumi Noda (M)

Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University.

Narandalai Danshiitsoodol (N)

Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University.

Takemasa Sakaguchi (T)

Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University.

Keishi Kanno (K)

Department of Gastroenterology, Hiroshima University Hospital.

Masanori Sugiyama (M)

Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University.

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Classifications MeSH