Identifying occult bladder outlet obstruction in women with detrusor-underactivity-like urodynamic profiles.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
01 12 2021
Historique:
received: 11 05 2021
accepted: 19 11 2021
entrez: 2 12 2021
pubmed: 3 12 2021
medline: 20 1 2022
Statut: epublish

Résumé

Voiding dysfunction can result from detrusor underactivity (DU), bladder outlet obstruction (BOO), or both. Conceptually, women with high-pressure low-flow urodynamic profiles are diagnosed with BOO without DU. However, the possibility of BOO is often neglected in women with DU-like (low-pressure low-flow) urodynamic (UDS) profiles. By reviewing the videourodynamic studies (VUDS) of 1678 women, our study identified the key factors suggesting urodynamic BOO (determined by radiographic evidence of obstruction) in women with DU-like UDS profiles (Pdet.Qmax < 20 cmH2O and Qmax < 15 mL/s). In 355 women with DU-like UDS profiles, there were 70 (19.7%) with BOO and 285 (80.3%) without BOO. The BOO group had predominantly obstructive symptoms. The BOO group showed significantly decreased bladder sensation, lower detrusor pressure (Pdet.Qmax), lower flow rate (Qmax), smaller voided volume, and larger post-voiding residual (PVR) compared to the non-BOO group. In multivariate analysis, volume at first sensation, Qmax, PVR, and detrusor overactivity (DO) remained independent factors for BOO. The receiver operating characteristic (ROC) areas for the parameters were largest for PVR (area = 0.786) and Qmax (area = 0.742). The best cut-off points were 220 mL for PVR and 4 mL/s for Qmax. Our findings provide simple indicators for BOO in women with DU.

Identifiants

pubmed: 34853346
doi: 10.1038/s41598-021-02617-0
pii: 10.1038/s41598-021-02617-0
pmc: PMC8636520
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

23242

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021. The Author(s).

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Auteurs

Po-Ming Chow (PM)

Department of Urology, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan.

Sheng-Mou Hsiao (SM)

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, No.21, Sec. 2, Nanya S. Rd., Banqiao Dist., New Taipei City, 220, Taiwan.
Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan.

Hann-Chorng Kuo (HC)

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, 707, Sec. 3, Chung-Yang Rd., Hualien, Taiwan. hck@tzuchi.com.tw.

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Classifications MeSH