Bacterial Colonization of the Condyle in Patients with Advanced Mandibular Osteoradionecrosis: Analysis of Hemimandibulectomy Specimens.
Journal
International journal of dentistry
ISSN: 1687-8728
Titre abrégé: Int J Dent
Pays: Egypt
ID NLM: 101524183
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
03
2021
accepted:
25
10
2021
entrez:
2
12
2021
pubmed:
3
12
2021
medline:
3
12
2021
Statut:
epublish
Résumé
Advanced mandibular osteoradionecrosis (ORN) sometimes requires extended resection (e.g., hemimandibulectomy). Bacterial infection contributes to ORN pathogenesis. To control infection and determine the extent of debridement required, an understanding of bacterial spread within sites of mandibular ORN is important. The current study used a histopathological approach to assess bacterial colonization in the mandibular condyle and elucidate possible paths of bacterial spread towards the mandibular condyle. Four hemimandibulectomy specimens were selected. Areas of bone destruction were macroscopically assessed and confirmed using hematoxylin and eosin staining. Bacterial presence within mandibular condyle was confirmed with Gram staining. Bone exposure was observed in the molar area in all specimens. Macroscopic bone destruction was apparent especially near the medial side of the cortical wall. Gram staining revealed bacterial colonization of the mandibular condyle in three of the four specimens. In conclusion, bacteria tended to spread posteriorly and through the medial side of the mandibular cortical wall. In patients with advanced ORN, the potential for bacterial colonization of the mandibular condyle should be considered during treatment.
Identifiants
pubmed: 34853593
doi: 10.1155/2021/9998397
pmc: PMC8629619
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9998397Informations de copyright
Copyright © 2021 Daisuke Takeda et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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