The Effect of Size and Asymmetry at Birth on Brain Injury and Neurodevelopmental Outcomes in Congenital Heart Disease.
Birth anthropometry
Birth asymmetry
Brain injury
Congenital heart disease
Neurodevelopment
Journal
Pediatric cardiology
ISSN: 1432-1971
Titre abrégé: Pediatr Cardiol
Pays: United States
ID NLM: 8003849
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
29
03
2021
accepted:
24
11
2021
pubmed:
3
12
2021
medline:
15
4
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Poor and asymmetric fetal growth have been associated with neonatal brain injury (BI) and worse neurodevelopmental outcomes (NDO) in the growth-restricted population due to placental insufficiency. We tested the hypothesis that postnatal markers of fetal growth (birthweight (BW), head circumference (HC), and head to body symmetry) are associated with preoperative white matter injury (WMI) and NDO in infants with single ventricle physiology (SVP) and d-transposition of great arteries (TGA). 173 term newborns (106 TGA; 67 SVP) at two sites had pre-operative brain MRI to assess for WMI and measures of microstructural brain development. NDO was assessed at 30 months with the Bayley Scale of Infant Development-II (n = 69). We tested the association between growth parameters at birth with the primary outcome of WMI on the pre-operative brain MRI. Secondary outcomes included measures of NDO. Newborns with TGA were more likely to have growth asymmetry with smaller heads relative to weight while SVP newborns were symmetrically small. There was no association between BW, HC or asymmetry and WMI on preoperative brain MRI or with measures of microstructural brain development. Similarly, growth parameters at birth were not associated with NDO at 30 months. In a multivariable model only cardiac lesion and site were associated with NDO. Unlike other high-risk infant populations, postnatal markers of fetal growth including head to body asymmetry that is common in TGA is not associated with brain injury or NDO. Lesion type appears to play a more important role in NDO in CHD.
Identifiants
pubmed: 34853878
doi: 10.1007/s00246-021-02798-5
pii: 10.1007/s00246-021-02798-5
pmc: PMC9005428
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
868-877Subventions
Organisme : NIH HHS
ID : NS082330
Pays : United States
Organisme : NIH HHS
ID : HD07274
Pays : United States
Organisme : NIH HHS
ID : NS099422
Pays : United States
Organisme : NIH HHS
ID : NS063876
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001271
Pays : United States
Organisme : NIH HHS
ID : NS40117
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS082330
Pays : United States
Organisme : NIH HHS
ID : EB009756
Pays : United States
Organisme : NCRR NIH HHS
ID : 5-M01-RR-01271
Pays : United States
Organisme : CIHR
ID : MOP93780
Pays : Canada
Organisme : NHLBI NIH HHS
ID : T32 HL007544
Pays : United States
Informations de copyright
© 2021. The Author(s).
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