Validation of the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients.

Amyotrophic Lateral Sclerosis / complications Deglutition Disorders / diagnosis Humans Middle Aged Multiple Sclerosis / diagnosis Quality of Life Surveys and Questionnaires
ALS Dysphagia Screening

Journal

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175

Informations de publication

Date de publication:
May 2022
Historique:
received: 28 07 2021
accepted: 19 11 2021
pubmed: 3 12 2021
medline: 22 4 2022
entrez: 2 12 2021
Statut: ppublish

Résumé

Dysphagia is a common symptom during the trajectory of ALS, and it can significantly impact on the quality of life and prognosis of patients. Nowadays, no specific tool for the screening of dysphagia in ALS is validated, and the approach is heterogeneous across the Italian centres. To validate the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire, adapting the DYMUS (dysphagia in multiple sclerosis) questionnaire, for the assessment of dysphagia in ALS patients, in order to uniform the evaluations across the Italian ALS network. We included 197 patients diagnosed with ALS following the El Escorial criteria, in sixteen Italian ALS centres between 1st December 2019 and 1st July 2020. For each patient, we collected clinical and demographic data and obtained ALSFRS-r score, ALSAQ-5 score, DYMUS score, and EAT-10 score. Across the 197 patients, the ratio M/F was 113/84, and the median age was 64 years (IQR 56-72.5). Bulbar patients were 20%, and spinal patients 80%. The median ALSFRSr total score of patients was 35 (IQR 28-39). DYALS score was statistically higher in bulbar ALS than in spinal ALS (median = 6, IQR 4.5-9 vs median = 1, IQR 0-5, z = 6.253, p < 0.0001). DYALS questionnaire showed a high internal consistency (Cronbach's alpha = 0.88). There was a statistically significant correlation between DYALS and EAT-10 (rho = 0.90, p < 0.0001). DYALS scale is reliable, manageable, and easily usable for the screening of dysphagia in ALS. It can be shared with all the Italian ALS centres in order to collect uniform data for therapeutic strategies and clinical trials.

Sections du résumé

BACKGROUND BACKGROUND
Dysphagia is a common symptom during the trajectory of ALS, and it can significantly impact on the quality of life and prognosis of patients. Nowadays, no specific tool for the screening of dysphagia in ALS is validated, and the approach is heterogeneous across the Italian centres.
OBJECTIVE OBJECTIVE
To validate the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire, adapting the DYMUS (dysphagia in multiple sclerosis) questionnaire, for the assessment of dysphagia in ALS patients, in order to uniform the evaluations across the Italian ALS network.
METHODS METHODS
We included 197 patients diagnosed with ALS following the El Escorial criteria, in sixteen Italian ALS centres between 1st December 2019 and 1st July 2020. For each patient, we collected clinical and demographic data and obtained ALSFRS-r score, ALSAQ-5 score, DYMUS score, and EAT-10 score.
RESULTS RESULTS
Across the 197 patients, the ratio M/F was 113/84, and the median age was 64 years (IQR 56-72.5). Bulbar patients were 20%, and spinal patients 80%. The median ALSFRSr total score of patients was 35 (IQR 28-39). DYALS score was statistically higher in bulbar ALS than in spinal ALS (median = 6, IQR 4.5-9 vs median = 1, IQR 0-5, z = 6.253, p < 0.0001). DYALS questionnaire showed a high internal consistency (Cronbach's alpha = 0.88). There was a statistically significant correlation between DYALS and EAT-10 (rho = 0.90, p < 0.0001).
CONCLUSIONS CONCLUSIONS
DYALS scale is reliable, manageable, and easily usable for the screening of dysphagia in ALS. It can be shared with all the Italian ALS centres in order to collect uniform data for therapeutic strategies and clinical trials.

Identifiants

DOI: 10.1007/s10072-021-05775-1 PMID: 34853898
pubmed: 34853898
doi: 10.1007/s10072-021-05775-1
pii: 10.1007/s10072-021-05775-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3195-3200

Subventions

Organisme : ministero della salute
ID : RC 2020-2021

Investigateurs

Giuliana Capece (G)
Andrea Ghezzi (A)
Giuseppe Fiamingo (G)
Francesco Pio Ausiello (FP)
Laura Ferri (L)
Alberto Doretti (A)
Eleonora Colombo (E)
Gianluca Demirtzidis (G)
Vittorio Riso (V)
Federica Bianchi (F)
Micol Castellari (M)
Francesca Madonia (F)
Marco Ceccanti (M)
Chiara Cambieri (C)
Laura Libonati (L)
Gaia Fanella (G)
Carlo Ferrarese (C)
Annalisa Gessani (A)
Carla Budriesi (C)
Fabiola De Marchi (F)
Francesca Bianchi (F)
Cecilia Carlesi (C)

Informations de copyright

© 2021. Fondazione Società Italiana di Neurologia.

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Auteurs

Luca Diamanti (L)

IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy. luca.diamanti@mondino.it.
ORCID: 0000-0002-4540-6886

Paola Borrelli (P)

Laboratory of Biostatistics, Department of Medical, Oral, and Biotechnological Sciences, University G. d'Annunzio Chieti-Pescara, Chieti, Italy.

Raffaele Dubbioso (R)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Margherita Capasso (M)

Neurologic Clinic, SS. Annunziata Hospital, Chieti, Italy.

Claudia Morelli (C)

Department of Neurology and Laboratory of Neuroscience, Istituto Auxologico Italiano, IRCCS, Milan, Italy.

Christian Lunetta (C)

NEMO Clinical Center, Serena Onlus Foundation, Milano, Italy.
NEMO Lab, Milano, Italy.

Antonio Petrucci (A)

Center for Neuromuscular and Neurological Rare Diseases, Neurology and Neurophysiology Unit, San Camillo Forlanini Hospital, Rome, Italy.

Gabriele Mora (G)

ICS Maugeri IRCCS, Milano, Italy.

Paolo Volanti (P)

Department of Neurorehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Institute of Mistretta, Messina, Italy.

Maurizio Inghilleri (M)

Neuromuscular Rare Disease Centre, Department Human Neurosciences, University of Rome La Sapienza, Rome, Italy.

Lucio Tremolizzo (L)

Neurology, San Gerardo Hospital and University of Milano-Bicocca, Monza, Italy.

Jessica Mandrioli (J)

Department of Biomedical, Metabolic and Neural Science, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Neurology Unit, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy.

Letizia Mazzini (L)

Department of Neurology and ALS Centre, University of Piemonte Orientale, Maggiore Della Carità Hospital, Novara, Italy.

Marcella Vedovello (M)

Neurology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.

Gabriele Siciliano (G)

Center for Neuromuscular and Neurological Rare Diseases Neurological Clinic, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Massimiliano Filosto (M)

Department of Clinical and Experimental Sciences, University of Brescia, NeMO-Brescia Clinical Center for Neuromuscular Diseases, Brescia, Italy.

Sabrina Matà (S)

SOD Neurologia 1, Dipartimento Neuromuscolo-Scheletrico E Degli Organi Di Senso, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.

Cristina Montomoli (C)

Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy.

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Validation of the DYALS (dysphagia in...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du pharynx › Troubles de la déglutition › Validation of the DYALS (dysphagia in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Validation of the DYALS (dysphagia in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Validation of the DYALS (dysphagia in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Validation of the DYALS (dysphagia in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Validation of the DYALS (dysphagia in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Validation of the DYALS (dysphagia in...