A case of cutaneous syncytial myoepithelioma with extensive adipocytic metaplasia: Usefulness of EWSR1-PBX3 gene fusion analysis.
EWSR1
PBX3
adipocyte
metaplasia
myoepithelioma
syncytial
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
04
11
2021
received:
13
09
2021
accepted:
28
11
2021
pubmed:
3
12
2021
medline:
29
3
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Cutaneous syncytial myoepithelioma (CSM) is a recently recognized variant of myoepithelioma characterized by an intradermal syncytial proliferation of spindled, ovoid, and histiocytoid cells. Immunohistochemically, tumor cells usually show strong expression of S-100 protein and epithelial membrane antigen (EMA). Here we report a case of CSM in the thigh of a 51-year-old Japanese woman. Histopathological findings showed a sheet-like growth of ovoid cells and histiocytoid cells with an eosinophilic syncytial cytoplasm, and adipocytic metaplasia was widely observed in the tumor. Immunohistochemical staining revealed a diffuse, strong pattern for EMA, smooth muscle actin (SMA), and HHF35, and variable expression of S-100 protein and p63 in ovoid and histiocytoid cells without significant mitotic figures or pleomorphism. In addition, EWSR1-PBX3 gene fusion, which is characteristic of CSM, was observed in the tumor. Based on these findings, we diagnosed the patient as having CSM. Our case shows that CSM can exhibit extensive adipocytic metaplasia, which could make its histopathological diagnosis challenging.
Substances chimiques
EWSR1 protein, human
0
Homeodomain Proteins
0
Proto-Oncogene Proteins
0
RNA-Binding Protein EWS
0
proto-oncogene protein Pbx3
146150-81-4
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
412-417Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
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