Biomaterials-based Approaches for Cardiac Regeneration.

Cardiovascular diseases Extracellular vesicles Heart failure Tissue engineering

Journal

Korean circulation journal
ISSN: 1738-5520
Titre abrégé: Korean Circ J
Pays: Korea (South)
ID NLM: 101247141

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 30 08 2021
accepted: 08 09 2021
entrez: 2 12 2021
pubmed: 3 12 2021
medline: 3 12 2021
Statut: ppublish

Résumé

The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration.

Identifiants

pubmed: 34854577
pii: 51.943
doi: 10.4070/kcj.2021.0291
pmc: PMC8636758
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

943-960

Subventions

Organisme : Korea Health Industry Development Institute
ID : HI19C0642
Pays : Republic of Korea

Informations de copyright

Copyright © 2021. The Korean Society of Cardiology.

Déclaration de conflit d'intérêts

Deok-Ho Kim is a scientific founder and equity holder of Curi Bio. Peter V. Johnston is a founder and equity holder of Domicell, and serves as a consultant to BioCardia, Inc. The other authors report no conflicts.

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Auteurs

Samhita Vasu (S)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Justin Zhou (J)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Jeffrey Chen (J)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Peter V Johnston (PV)

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Deok-Ho Kim (DH)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. dhkim@jhu.edu.

Classifications MeSH