PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling.
NLRP3
inflammasome
inflammation
phosphorylation/dephosphorylation
post translational modification
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
17 12 2021
17 12 2021
Historique:
received:
07
09
2021
revised:
07
10
2021
accepted:
11
10
2021
pubmed:
3
12
2021
medline:
2
4
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Inflammasomes are protein complexes in the innate immune system that regulate the production of pro-inflammatory cytokines and inflammatory cell death. Inflammasome activation and subsequent cell death often occur within minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome proteins has emerged as a key regulatory step in inflammasome activation. Phosphorylation of inflammasome sensor and adapter proteins regulates their inter- and intra-molecular interactions, subcellular localisation, and function. The control of inflammasome phosphorylation may thus provide a new strategy for the development of anti-inflammatory therapeutics. Herein we describe the current knowledge of how phosphorylation operates as a critical switch for inflammasome signalling.
Identifiants
pubmed: 34854899
pii: 230355
doi: 10.1042/BST20200987
pmc: PMC8786285
doi:
Substances chimiques
Inflammasomes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2495-2507Subventions
Organisme : Medical Research Council
ID : MR/S000623/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W001217/1
Pays : United Kingdom
Informations de copyright
© 2021 The Author(s).
Références
Science. 2002 Dec 6;298(5600):1912-34
pubmed: 12471243
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14384-14389
pubmed: 27911804
Nat Commun. 2021 May 11;12(1):2674
pubmed: 33976226
Mol Cell. 2013 Jan 24;49(2):331-8
pubmed: 23246432
Front Immunol. 2021 Apr 02;12:661162
pubmed: 33868312
Rheumatology (Oxford). 2018 Jan 1;57(1):100-111
pubmed: 29040788
J Exp Med. 2017 Sep 4;214(9):2671-2693
pubmed: 28716882
J Exp Med. 2004 Feb 16;199(4):449-58
pubmed: 14970175
J Exp Med. 2021 Nov 1;218(11):
pubmed: 34554188
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31611248
EMBO Mol Med. 2019 Nov 7;11(11):e10547
pubmed: 31589380
Nat Commun. 2018 Dec 5;9(1):5182
pubmed: 30518920
J Exp Med. 2016 May 30;213(6):877-85
pubmed: 27139490
Br J Pharmacol. 2020 Oct;177(19):4416-4432
pubmed: 32608058
Nat Genet. 1997 Sep;17(1):25-31
pubmed: 9288094
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
J Leukoc Biol. 2015 May;97(5):825-835
pubmed: 25605870
Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):
pubmed: 34518217
Nat Commun. 2021 May 11;12(1):2713
pubmed: 33976225
Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20
pubmed: 25514926
Nature. 2009 Mar 26;458(7237):509-13
pubmed: 19158676
J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10
pubmed: 28216434
J Biol Chem. 2011 Mar 18;286(11):9587-97
pubmed: 21228274
J Biol Chem. 2008 Feb 29;283(9):5402-13
pubmed: 18086677
Nat Immunol. 2016 Aug;17(8):914-21
pubmed: 27270401
Elife. 2021 Jan 07;10:
pubmed: 33410748
Nature. 2019 Jun;570(7761):338-343
pubmed: 31189953
Front Immunol. 2019 Jul 05;10:1556
pubmed: 31333677
Nat Commun. 2016 Dec 08;7:13727
pubmed: 27929086
Autophagy. 2017 Sep 2;13(9):1590-1601
pubmed: 28786745
Nature. 2018 Dec;564(7734):71-76
pubmed: 30487600
Sci Transl Med. 2016 Mar 30;8(332):332ra45
pubmed: 27030597
Nat Med. 2009 Oct;15(10):1170-8
pubmed: 19767732
Curr Drug Targets. 2014 Jan;15(1):65-79
pubmed: 24387334
Nat Immunol. 2016 Oct;17(10):1176-86
pubmed: 27548431
Immunol Rev. 2020 Sep;297(1):67-82
pubmed: 32729154
Nat Chem Biol. 2013 Jun;9(6):398-405
pubmed: 23603659
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6
pubmed: 25605939
Science. 1998 Nov 13;282(5392):1318-21
pubmed: 9812896
Nature. 2012 Aug 30;488(7413):670-4
pubmed: 22801494
J Immunol. 2020 Oct 15;205(8):2255-2264
pubmed: 32929041
J Exp Med. 2020 Jul 6;217(7):
pubmed: 32342103
J Immunol. 2012 Oct 15;189(8):3795-9
pubmed: 22984081
J Exp Med. 2017 Oct 2;214(10):3051-3066
pubmed: 28821568
Ann Rheum Dis. 2021 Jan;80(1):128-132
pubmed: 33037005
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E944-53
pubmed: 22451944
Nat Immunol. 2017 Mar 22;18(4):374-384
pubmed: 28323260
Nat Cell Biol. 2020 Jun;22(6):716-727
pubmed: 32367047
J Cell Biochem. 2019 Oct;120(10):17744-17756
pubmed: 31210372
Arthritis Rheum. 2005 Jun;52(6):1848-57
pubmed: 15934090
Nature. 2009 Mar 26;458(7237):514-8
pubmed: 19158675
J Cell Biol. 2015 Sep 14;210(6):973-89
pubmed: 26347139
EMBO Rep. 2020 Jul 3;21(7):e49666
pubmed: 32352641
Nat Genet. 2006 Feb;38(2):240-4
pubmed: 16429160
Nature. 2021 Mar;591(7849):300-305
pubmed: 33505023
Cell Mol Immunol. 2017 Jan;14(1):65-79
pubmed: 27345727
Nat Med. 2015 Aug;21(8):906-13
pubmed: 26107252
Nat Rev Drug Discov. 2018 Aug;17(8):588-606
pubmed: 30026524
J Exp Med. 2017 Jun 5;214(6):1725-1736
pubmed: 28465465
J Clin Invest. 2016 May 2;126(5):1783-800
pubmed: 27043286
Science. 2020 Dec 4;370(6521):
pubmed: 33093214
Nat Rev Immunol. 2019 Aug;19(8):477-489
pubmed: 31036962
Immunity. 2016 Oct 18;45(4):802-816
pubmed: 27692610
Nat Commun. 2015 Jun 10;6:7360
pubmed: 26059659
Nature. 2015 Oct 29;526(7575):666-71
pubmed: 26375259
Science. 2009 Feb 20;323(5917):1057-60
pubmed: 19131592
Nat Immunol. 2020 Aug;21(8):857-867
pubmed: 32601469
Nature. 2012 Oct 25;490(7421):539-42
pubmed: 22885697
Front Immunol. 2019 Nov 28;10:2791
pubmed: 31849970
Nat Cell Biol. 2003 Jul;5(7):647-54
pubmed: 12792650
J Biol Chem. 2005 Feb 11;280(6):4279-88
pubmed: 15561713
Nat Microbiol. 2021 Mar;6(3):401-412
pubmed: 33432150
Nat Immunol. 2013 Dec;14(12):1247-55
pubmed: 24185614
J Immunol. 2021 Mar 15;206(6):1329-1336
pubmed: 33568399
Trends Biochem Sci. 2018 Sep;43(9):685-699
pubmed: 30049633
Nat Commun. 2014 Sep 30;5:4977
pubmed: 25266676
Cell Syst. 2017 Apr 26;4(4):430-444.e5
pubmed: 28330616
Elife. 2021 May 14;10:
pubmed: 33988507
Mol Cell. 2017 Oct 5;68(1):185-197.e6
pubmed: 28943315
Science. 2021 Jan 29;371(6528):
pubmed: 33243852
EMBO J. 2020 Jan 15;39(2):e103397
pubmed: 31793683
Sci Rep. 2016 Oct 31;6:36214
pubmed: 27796369
Nat Cell Biol. 2002 May;4(5):E127-30
pubmed: 11988757
Nat Commun. 2019 Apr 11;10(1):1689
pubmed: 30976076
Nat Rev Immunol. 2017 Mar;17(3):208-214
pubmed: 28163301
Nat Rev Immunol. 2016 Jul;16(7):407-20
pubmed: 27291964
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4857-66
pubmed: 27482109
Nat Immunol. 2012 Jan 29;13(3):255-63
pubmed: 22286270
Nature. 2016 Feb 18;530(7590):354-7
pubmed: 26814970
Structure. 2017 Jan 3;25(1):27-39
pubmed: 27889207
Eur J Immunol. 2013 May;43(5):1147-52
pubmed: 23401008
PLoS One. 2021 Nov 12;16(11):e0248668
pubmed: 34767572
J Leukoc Biol. 2020 Sep;108(3):937-952
pubmed: 32745339
J Clin Invest. 2020 Apr 1;130(4):1793-1807
pubmed: 31895698
Mol Cell Proteomics. 2011 Jan;10(1):M110.004457
pubmed: 20860994
Annu Rev Immunol. 2009;27:519-50
pubmed: 19302047
Cell. 1997 Aug 22;90(4):797-807
pubmed: 9288758
Science. 2013 Jul 12;341(6142):172-5
pubmed: 23765277
Cell Host Microbe. 2016 Sep 14;20(3):296-306
pubmed: 27569559