Intestinal toll-like receptor 4 knockout alters the functional capacity of the gut microbiome following irinotecan treatment.
Animals
Cell Line, Tumor
Colorectal Neoplasms
/ drug therapy
Fecal Microbiota Transplantation
/ methods
Gastrointestinal Diseases
/ chemically induced
Gastrointestinal Microbiome
/ drug effects
Irinotecan
/ pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
RNA, Ribosomal, 16S
Toll-Like Receptor 4
/ genetics
Topoisomerase I Inhibitors
/ pharmacology
Chemotherapy
Fecal microbiota transplant
Mucositis
Toll-like receptor 4
Journal
Cancer chemotherapy and pharmacology
ISSN: 1432-0843
Titre abrégé: Cancer Chemother Pharmacol
Pays: Germany
ID NLM: 7806519
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
30
08
2021
accepted:
22
11
2021
pubmed:
3
12
2021
medline:
17
2
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Irinotecan can cause high levels of diarrhea caused by toxic injury to the gastrointestinal microenvironment. Toll-like receptor 4 (TLR4) and the gut microbiome have previously been implicated in gastrointestinal toxicity and diarrhea; however, the link between these two factors has not been definitively determined. We used a tumor-bearing, intestinal epithelial cell (IEC) TLR4 knockout model (Tlr4 MC-38 colorectal cancer cells were injected into WT and Tlr4 In study 1, there were no compositional differences in the microbiome between Tlr4 Tlr4
Identifiants
pubmed: 34854953
doi: 10.1007/s00280-021-04382-3
pii: 10.1007/s00280-021-04382-3
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Tlr4 protein, mouse
0
Toll-Like Receptor 4
0
Topoisomerase I Inhibitors
0
Irinotecan
7673326042
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
275-281Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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