Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients.
Aerobic exercise
End-stage renal disease
Haemodialysis
Inflammation
Intradialytic cycling
Microparticles
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
08
09
2021
accepted:
09
11
2021
pubmed:
3
12
2021
medline:
15
3
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Patients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact of regular, moderate-intensity IDC on circulating MPs and inflammatory markers in unit-based HD patients. Patients were cluster-randomised to intervention (n = 20, age: 51.4 ± 18.1 years, body mass: 77.6 ± 18.3 kg, mean ± SD) or no-exercise control (n = 20, 56.8 ± 14.0 years, 80.5 ± 26.5 kg). Intervention participants completed 30 min of moderate intensity (rating of perceived exertion [RPE] of 12-14) IDC, thrice weekly for 6 months. Pre-dialysis venous blood samples were obtained at 0, 3 and 6 months. Circulating MP phenotypes, cytokines, chemokine and MP TF expression were quantified using flow cytometry and cytometric bead array assays. Despite high exercise compliance (82%), no IDC-dependent effects were observed for any MP, cytokine or chemokine measure (p ≥ 0.051, η Six months of regular, moderate-intensity IDC had no effect on MPs, cytokines or chemokines. This suggests that the exercise did not exacerbate thrombotic or inflammatory status, though further functional assays are required to confirm this. ISRCTN1129707, prospectively registered on 05/03/2015.
Identifiants
pubmed: 34854982
doi: 10.1007/s00421-021-04846-7
pii: 10.1007/s00421-021-04846-7
pmc: PMC8854296
doi:
Substances chimiques
Biomarkers
0
Banques de données
ISRCTN
['ISRCTN1129707']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
599-609Subventions
Organisme : NIHR
ID : CS-2013-13-014
Organisme : NIHR
ID : DRF-2016-09-015
Informations de copyright
© 2021. The Author(s).
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