Improved Survival and Regeneration of Irradiated Mouse Neural Stem Cells after Co-Culturing with Non-Irradiated Mouse Neural Stem Cells or Mesenchymal Stem Cells from the Adipose Tissue.
Adipose Tissue
/ cytology
Animals
Apoptosis
/ radiation effects
Cell Survival
/ radiation effects
Cells, Cultured
Cellular Senescence
/ physiology
Coculture Techniques
Colony-Forming Units Assay
Gamma Rays
/ adverse effects
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ cytology
Mice
Mice, Inbred C57BL
Neural Stem Cells
/ cytology
cell therapy
mesenchymal stem cells
neural stem cells
senescence
γ-radiation
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
20
05
2021
pubmed:
3
12
2021
medline:
29
3
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
We studied the effect of neural stem cells (NSC) and mesenchymal stem cells (MSC) from mouse adipose tissue on survival, clonogenic activity, and senescence of NSC after exposure to γ-radiation. It was found that survival and clonogenic activity of NSC irradiated in doses of 1 and 2 Gy was enhanced when irradiated cells were co-cultured with non-irradiated NSC and MSC in permeable Transwell inserts. The proportion of senescent NSC (cells with high β-galactosidase activity) increased with increasing irradiation dose. Co-culturing with non-irradiated NSC in 3 days after irradiation in a dose of 1 Gy led to a decrease in the proportion of senescent cells among irradiated NSC. Factors secreted by NSC and MSC can become the basis for the development of means for prevention and treatment of damage to brain cells resulting from radiation therapy of head and neck cancer.
Identifiants
pubmed: 34855083
doi: 10.1007/s10517-021-05368-0
pii: 10.1007/s10517-021-05368-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-235Informations de copyright
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
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