The gut microbiota in retinal diseases.
Age-related macular degeneration
Diabetic retinopathy
Glaucoma
Gut microbiota
Probiotics
Retina
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
15
07
2021
revised:
25
10
2021
accepted:
23
11
2021
pubmed:
3
12
2021
medline:
12
2
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
The gut microbiota is a complex ecosystem that inhabits the gastrointestinal tract and consists of archaea, fungi, viruses, and bacteria, with bacteria being dominant. From birth onwards, it coevolves dynamically together with the host. The composition of the gut microbiota is under the influence of a complex interplay between both host and environmental factors. Scientific advances in the past few decades have shown that it is essential in maintaining homeostasis and tipping the balance between health and disease. In addition to its role in food digestion, the gut microbiota is implicated in regulating multiple physiological processes in the host gut mucosa and in distant organs such as the brain. Persistent imbalance between gut microbial communities, termed "dysbiosis," has been associated with several inflammatory and metabolic diseases as well as with central nervous system disorders. In this review, we present the state of the art of current knowledge on an emerging concept, the microbiota-retina axis, and the potential role of its disturbance in the development of retinopathies. We also describe several microbiota-targeting strategies that could constitute preventive and therapeutic tools for retinopathies.
Identifiants
pubmed: 34856206
pii: S0014-4835(21)00433-4
doi: 10.1016/j.exer.2021.108867
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108867Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.