Synthesis and characterization of chitosan nanoparticles loaded with greater celandine (Chelidonium majus L.) essential oil as an anticancer agent on MCF-7 cell line.

Antineoplastic Agents / chemical synthesis Cell Survival / drug effects Chelidonium / chemistry Chemical Phenomena Chemistry Techniques, Synthetic Chitosan / chemistry Drug Compounding Gas Chromatography-Mass Spectrometry Humans MCF-7 Cells Nanoparticles / chemistry Oils, Volatile / chemistry Spectroscopy, Fourier Transform Infrared
Apoptosis Breast cancer Chelidonium majus L. Chitosan nanoparticles Encapsulation

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Jan 2022
Historique:
received: 10 09 2021
revised: 03 11 2021
accepted: 22 11 2021
pubmed: 3 12 2021
medline: 18 3 2022
entrez: 2 12 2021
Statut: ppublish

Résumé

Essential oils (EOs) of greater celandine (GC) roots and leaves were extracted, and gas chromatography-mass spectrometry (GC-MS) was used for analyzing them. Then they were loaded into chitosan nanoparticles (CNPs) using emulsion-ionic gelation method. CNPs loaded with greater celandine root essential oil (GCREO) and leave essential oil (GCLEO) were synthesized (size 76.5-115.3 nm) using an emulsion-ionic gelation method. Fourier Transform Infrared (FT-IR), spectroscopy, scanning electron microscope (SEM), and dynamic light scattering (DLS) were used for characterization of the formed NPs. Good encapsulation efficiency was confirmed for GCREO (62.5%) and GCLEO (69.1%) in CNPs. According to the MTT results, the synthesized NPs showed a dose-dependent effect on MCF-7 cell line. The inhibitory concentration (IC

Identifiants

DOI: 10.1016/j.ijbiomac.2021.11.155 PMID: 34856216
pubmed: 34856216
pii: S0141-8130(21)02561-7
doi: 10.1016/j.ijbiomac.2021.11.155
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Oils, Volatile 0
Chitosan 9012-76-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

974-981

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Sadra Hesami (S)

Department of Horticulture Science (Medicinal Plants), Science and Research Branch, Islamic Azad University, Tehran, Iran.

Shahabeddin Safi (S)

Department of Pathobiology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: S.safi@srbiau.ac.ir.

Kambiz Larijani (K)

Department of Chemistry, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Hassanali Naghdi Badi (HN)

Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.

Vahid Abdossi (V)

Department of Horticulture Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Milad Hadidi (M)

Department of Organic Chemistry, Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha, Ciudad Real, Spain. Electronic address: milad.hadidi@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Synthesis and characterization of chitosan...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Synthesis and characterization of chitosan...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Ranunculales › Papaveraceae › Chelidonium › Synthesis and characterization of chitosan...
questionsmedicales.fr › Phénomènes chimiques › Synthesis and characterization of chitosan...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Synthesis and characterization of chitosan...
questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › Synthesis and characterization of chitosan...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Synthesis and characterization of chitosan...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Chromatographie gazeuse-spectrométrie de masse › Synthesis and characterization of chitosan...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and characterization of chitosan...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Synthesis and characterization of chitosan...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Synthesis and characterization of chitosan...
questionsmedicales.fr › Lipides › Huiles › Huile essentielle › Synthesis and characterization of chitosan...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › Spectroscopie infrarouge à transformée de Fourier › Synthesis and characterization of chitosan...