Effect of oxygen therapy on exercise performance in patients with cyanotic congenital heart disease: Randomized-controlled trial.

Adult Exercise Test Female Heart Defects, Congenital / diagnosis Humans Hypoxia Oxygen Oxygen Saturation Single-Blind Method
Cyanotic congenital heart disease Eisenmenger Exercise performance Oxygen Oxygen therapy Pulmonary hypertension

Journal

International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291

Informations de publication

Date de publication:
01 Feb 2022
Historique:
received: 03 06 2021
revised: 25 11 2021
accepted: 26 11 2021
pubmed: 3 12 2021
medline: 27 1 2022
entrez: 2 12 2021
Statut: ppublish

Résumé

Patients with unrepaired cyanotic congenital heart disease (CHD) suffer from aggravated hypoxemia during exercise. We tested the hypothesis that supplemental oxygen improves exercise performance in these patients. In this randomized, sham-controlled, single-blind, cross-over trial cyanotic CHD-patients underwent four cycle exercise tests to exhaustion, while breathing either oxygen-enriched (FiO We included seven patients with cyanotic CHD (4 Eisenmenger syndrome, 3 unrepaired cyanotic defects, 4 women) median (quartiles) age 36 (32;50) years, BMI 23 (20;26) kg/m Patients with cyanotic CHD significantly improved their exercise performance, in terms of maximal work-rate and endurance time along with an improved arterial oxygenation and ventilatory efficiency with supplemental oxygen compared to air.

Sections du résumé

BACKGROUND BACKGROUND
Patients with unrepaired cyanotic congenital heart disease (CHD) suffer from aggravated hypoxemia during exercise. We tested the hypothesis that supplemental oxygen improves exercise performance in these patients.
METHODS METHODS
In this randomized, sham-controlled, single-blind, cross-over trial cyanotic CHD-patients underwent four cycle exercise tests to exhaustion, while breathing either oxygen-enriched (FiO
RESULTS RESULTS
We included seven patients with cyanotic CHD (4 Eisenmenger syndrome, 3 unrepaired cyanotic defects, 4 women) median (quartiles) age 36 (32;50) years, BMI 23 (20;26) kg/m
CONCLUSIONS CONCLUSIONS
Patients with cyanotic CHD significantly improved their exercise performance, in terms of maximal work-rate and endurance time along with an improved arterial oxygenation and ventilatory efficiency with supplemental oxygen compared to air.

Identifiants

DOI: 10.1016/j.ijcard.2021.11.066 PMID: 34856290
pubmed: 34856290
pii: S0167-5273(21)01956-2
doi: 10.1016/j.ijcard.2021.11.066
pii:
doi:

Substances chimiques

Oxygen S88TT14065

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

65-72

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Stéphanie Saxer (S)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland.

Luigi-Riccardo Calendo (LR)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland; Zurich University of Applied Sciences, ZHAW, Institute of Physiotherapy, Winterthur, Switzerland.

Mona Lichtblau (M)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland.

Arcangelo Carta (A)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland.

Julian Müller (J)

Zurich University of Applied Sciences, ZHAW, Institute of Physiotherapy, Winterthur, Switzerland; University Hospital Zurich, Department of Pulmonology, Switzerland.

Fiorenza Gautschi (F)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland.

Charlotte Berlier (C)

University Hospital Zurich, Department of Pulmonology, Switzerland.

Michael Furian (M)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland.

Esther I Schwarz (EI)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland.

Konrad E Bloch (KE)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland; Center for Human Integrative Physiology, and Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Switzerland.

Matthias Greutmann (M)

University Hospital Zurich, Adult Congenital Heart Disease Program, University Heart Center, University of Zurich, Switzerland.

Silvia Ulrich (S)

Clinic of Pulmonology, University Hospital of Zurich, Switzerland; Center for Human Integrative Physiology, and Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Switzerland. Electronic address: silvia.ulrich@usz.ch.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Effect of oxygen therapy on exercise...
questionsmedicales.fr › Techniques d'investigation › Ergométrie › Épreuve d'effort › Effect of oxygen therapy on exercise...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Effect of oxygen therapy on exercise...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of oxygen therapy on exercise...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Effect of oxygen therapy on exercise...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Effect of oxygen therapy on exercise...
questionsmedicales.fr › Métabolisme › Saturation en oxygène › Effect of oxygen therapy on exercise...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méthode en simple aveugle › Effect of oxygen therapy on exercise...