A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis.

Antibodies, Viral BNT162 Vaccine COVID-19 Humans Renal Dialysis / adverse effects SARS-CoV-2 Vaccines, Synthetic mRNA Vaccines
BNT162b2 COVID-19 SARS-CoV-2 hemodialysis mRNA vaccine

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
02 2022
Historique:
received: 09 07 2021
revised: 20 10 2021
accepted: 26 10 2021
pubmed: 3 12 2021
medline: 29 1 2022
entrez: 2 12 2021
Statut: ppublish

Résumé

The level of protection achieved by the standard two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) remains unclear. To study this we used the French Renal Epidemiology and Information Network (REIN) Registry to compare the incidence and severity of 1474 cases of COVID-19 diagnosed in patients receiving MHD after none, one or two doses of vaccine. Vaccination significantly reduce COVID-19 incidence and severity, but 11% of patients infected after two doses still died. Lack of vaccinal protection in patients naïve for SARS-CoV-2 could be due to defective Tfh response [38% of patients with negative spike-specific CD4

Identifiants

DOI: 10.1016/j.kint.2021.10.040 PMID: 34856313 PMC: PMC8628628
pubmed: 34856313
pii: S0085-2538(21)01085-1
doi: 10.1016/j.kint.2021.10.040
pmc: PMC8628628
pii:
doi:

Substances chimiques

Antibodies, Viral 0
Vaccines, Synthetic 0
mRNA Vaccines 0
BNT162 Vaccine N38TVC63NU

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

390-402

Investigateurs

Chantrel François (C)
Reydit Mathilde (R)
Tiple Aurélien (T)
Bechade Clémence (B)
Bemrah Abdelkader (B)
Vigneau Cécile (V)
Sautenent Bénédicte (S)
Kazes Isabelle (K)
Courivaud Cécile (C)
Gabriel Jean-Marc (G)
Edet Stéphane (E)
Mercadal Lucile (M)
Moranne Olivier (M)
Toure Fatouma (T)
Laurain Emmanuelle (L)
Ranlin Alex (R)
Longlune Nathalie (L)
Glowacki François (G)
Tivollier Jean-Michel (T)
Brunet Philippe (B)
Lavainne Fréderic (L)
Berard Etienne (B)
Sarraj Ayman (S)
Bauwens Marc (B)
Testevuide Pascale (T)
Vacher Coponat Henri (VC)
Galland Roula (G)
Schauder Nicole (S)
Salmi Louis-Rachid (S)
Cerasuolo Damiano (C)
Tendron-Franzin Anaïs (TF)
Bayat Sahar (B)
Halimi Jean Michel (HJ)
Wolak Aurore (W)
Gentile Stéphanie (G)
Devictor Bénédicte (D)
Monnet Elisabeth (M)
Boucaut Maitre Denis (BM)
Nacher Mathieu (N)
Merle Véronique (M)
Jais Jean-Philippe (J)
Daures Jean-Pierre (D)
Vergnenegre Alain (V)
Loos-Ayav Carole (LA)
Merle Sylvie (M)
Hazzan Marc (H)
Gervolino Shirley (G)
Nguyen Jean-Michel (N)
Iacobelli Silvia (I)

Informations de copyright

Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Maxime Espi (M)

Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique Unité Mixte de Recherch 5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France; Department of Nephrology, Nutrition, and Hemodialysis, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.

Xavier Charmetant (X)

Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique Unité Mixte de Recherch 5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France.

Thomas Barba (T)

Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique Unité Mixte de Recherch 5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France; Department of Internal Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France; Medical School, Claude Bernard University (Lyon 1), Villeurbanne, France.

Cyrille Mathieu (C)

Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique Unité Mixte de Recherch 5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France.

Caroline Pelletier (C)

Department of Nephrology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Laetitia Koppe (L)

Department of Nephrology, Nutrition, and Hemodialysis, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France; Medical School, Claude Bernard University (Lyon 1), Villeurbanne, France.

Elodie Chalencon (E)

Department of Nephrology, Nutrition, and Hemodialysis, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.

Emilie Kalbacher (E)

Department of Nephrology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Virginie Mathias (V)

Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique Unité Mixte de Recherch 5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France; Human Leukocyte Antigen Laboratory, French National Blood Service, Décines-Charpieu, France.

Anne Ovize (A)

Eurofins Biomnis Laboratory, Lyon, France.

Emmanuelle Cart-Tanneur (E)

Eurofins Biomnis Laboratory, Lyon, France.

Christine Bouz (C)

Eurofins Biomnis Laboratory, Lyon, France.

Laurence Pellegrina (L)

Eurofins Biomnis Laboratory, Lyon, France.

Emmanuel Morelon (E)

Medical School, Claude Bernard University (Lyon 1), Villeurbanne, France; Department of Transplantation, Nephrology, and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Laurent Juillard (L)

Medical School, Claude Bernard University (Lyon 1), Villeurbanne, France; Department of Nephrology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Denis Fouque (D)

Department of Nephrology, Nutrition, and Hemodialysis, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France; Medical School, Claude Bernard University (Lyon 1), Villeurbanne, France.

Cécile Couchoud (C)

REIN Registry, Agence de la Biomédecine, Saint-Denis La Plaine, France; Biostatistique Santé Department, Laboratoire de Biométrie et Biologie Evolutive, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5558, Université Lyon I, Villeurbanne, France.

Olivier Thaunat (O)

Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique Unité Mixte de Recherch 5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France; Medical School, Claude Bernard University (Lyon 1), Villeurbanne, France; Department of Transplantation, Nephrology, and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. Electronic address: olivier.thaunat@chu-lyon.fr.

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Classifications MeSH

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questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › A prospective observational study for...
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