The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function.
Area postrema
Gene therapy
Glucose metabolism
Hippocampus
Long-term potentiation
Metabolomics
Tauopathy
Thioredoxin
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
10
11
2021
accepted:
22
11
2021
pubmed:
3
12
2021
medline:
3
12
2021
entrez:
2
12
2021
Statut:
aheadofprint
Résumé
The nucleoredoxin gene NXNL2 encodes for two products through alternative splicing, rod-derived cone viability factor-2 (RdCVF2) that mediates neuronal survival and the thioredoxin-related protein (RdCVF2L), an enzyme that regulates the phosphorylation of TAU. To investigate the link between NXNL2 and tauopathies, we studied the Nxnl2 knockout mouse (Nxnl2
Identifiants
pubmed: 34856436
pii: S2213-2317(21)00358-X
doi: 10.1016/j.redox.2021.102198
pmc: PMC8640531
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102198Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.