Public health implications of SARS-CoV-2 variants of concern: a rapid scoping review.


Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
02 12 2021
Historique:
entrez: 3 12 2021
pubmed: 4 12 2021
medline: 15 12 2021
Statut: epublish

Résumé

The four SARS-CoV-2 variants of concern (VOC; Alpha, Beta, Gamma and Delta) identified by May 2021 are highly transmissible, yet little is known about their impact on public health measures. We aimed to synthesise evidence related to public health measures and VOC. A rapid scoping review. On 11 May 2021, seven databases (MEDLINE, Embase, the Cochrane Database of Systematic Reviews, Central Register of Controlled Trials, Epistemonikos' L-OVE on COVID-19, medRxiv, bioRxiv) were searched for terms related to VOC, public health measures, transmission and health systems. No limit was placed on date of publication. Studies were included if they reported on any of the four VOCs and public health measures, and were available in English. Only studies reporting on data collected after October 2020, when the first VOC was reported, were included. Titles, abstracts and full-text articles were screened by two independent reviewers. Data extraction was completed by two independent reviewers using a standardised form. Data synthesis and reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Of the 37 included studies, the majority assessed the impact of Alpha (n=32) and were conducted in Europe (n=12) or the UK (n=9). Most were modelling studies (n=28) and preprints (n=28). The majority of studies reported on infection control measures (n=17), followed by modifying approaches to vaccines (n=13), physical distancing (n=6) and either mask wearing, testing or hand washing (n=2). Findings suggest an accelerated vaccine rollout is needed to mitigate the spread of VOC. The increased severity of VOC requires proactive public health measures to control their spread. Further research is needed to strengthen the evidence for continued implementation of public health measures in conjunction with vaccine rollout. With no studies reporting on Delta, there is a need for further research on this and other emerging VOC on public health measures.

Identifiants

pubmed: 34857582
pii: bmjopen-2021-055781
doi: 10.1136/bmjopen-2021-055781
pmc: PMC8640198
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e055781

Informations de copyright

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Mari Somerville (M)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.
Department of Pediatrics, IWK Health, Halifax, Nova Scotia, Canada.

Janet A Curran (JA)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada jacurran@dal.ca.
Department of Pediatrics, IWK Health, Halifax, Nova Scotia, Canada.

Justine Dol (J)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Leah Boulos (L)

Maritime SPOR SUPPORT Unit, Nova Scotia Health, Halifax, Nova Scotia, Canada.

Lynora Saxinger (L)

Division of Infectious Diseases, Department of Medicine, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada.

Alexander Doroshenko (A)

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Stephanie Hastings (S)

Health Systems Evaluation and Evidence, Alberta Health Services, Calgary, Alberta, Canada.

Bearach Reynolds (B)

Department of Infectious Diseases, St Vincents Hospital, Dublin, Leinster, UK.
Evidence Synthesis Ireland, National University of Ireland, Galway, UK.

Allyson J Gallant (AJ)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Hwayeon Danielle Shin (HD)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Helen Wong (H)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Daniel Crowther (D)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Marilyn Macdonald (M)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Ruth Martin-Misener (R)

Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

Jeannette Comeau (J)

Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Division of Infectious Diseases, IWK Health, Halifax, Nova Scotia, Canada.

Holly McCulloch (H)

Department of Pediatrics, IWK Health, Halifax, Nova Scotia, Canada.

Andrea C Tricco (AC)

Knowledge Translation Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Epidemiology Division and Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Queen's Collaboration for Health Care Quality Joanna Briggs Institute Centre of Excellence, School of Nursing, Queen's University, Kingston, Ontario, Canada.

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