Theta rhythmicity governs human behavior and hippocampal signals during memory-dependent tasks.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 12 2021
02 12 2021
Historique:
received:
08
03
2021
accepted:
27
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
5
1
2022
Statut:
epublish
Résumé
Memory formation and reinstatement are thought to lock to the hippocampal theta rhythm, predicting that encoding and retrieval processes appear rhythmic themselves. Here, we show that rhythmicity can be observed in behavioral responses from memory tasks, where participants indicate, using button presses, the timing of encoding and recall of cue-object associative memories. We find no evidence for rhythmicity in button presses for visual tasks using the same stimuli, or for questions about already retrieved objects. The oscillations for correctly remembered trials center in the slow theta frequency range (1-5 Hz). Using intracranial EEG recordings, we show that the memory task induces temporally extended phase consistency in hippocampal local field potentials at slow theta frequencies, but significantly more for remembered than forgotten trials, providing a potential mechanistic underpinning for the theta oscillations found in behavioral responses.
Identifiants
pubmed: 34857748
doi: 10.1038/s41467-021-27323-3
pii: 10.1038/s41467-021-27323-3
pmc: PMC8639755
doi:
Banques de données
figshare
['10.6084/m9.figshare.c.5192567', '10.6084/m9.figshare.13213769']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7048Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 10762/Z/15/Z
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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