NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.

Animals Anxiety / genetics DNA Glycosylases / genetics Gene Expression Regulation Hippocampus / physiology Learning Male Mice / genetics Mice, Knockout Oxidative Stress / physiology

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
02 12 2021
Historique:
received: 08 02 2021
accepted: 02 11 2021
entrez: 3 12 2021
pubmed: 4 12 2021
medline: 28 12 2021
Statut: epublish

Résumé

Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases affect cognition in mice, while the role of NEIL2 remains unclear. Here, we investigate the impact of NEIL2 and its potential overlap with NEIL1 on behavior in knockout mouse models. Neil1

Identifiants

DOI: 10.1038/s42003-021-02864-x PMID: 34857879 PMC: PMC8639745
pubmed: 34857879
doi: 10.1038/s42003-021-02864-x
pii: 10.1038/s42003-021-02864-x
pmc: PMC8639745
doi:

Substances chimiques

DNA Glycosylases EC 3.2.2.-
Neil1 protein, mouse EC 3.2.2.-
Neil2 protein, mouse EC 3.2.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1354

Informations de copyright

© 2021. The Author(s).

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Auteurs

Gunn A Hildrestrand (GA)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
ORCID: 0000-0003-3160-7203

Veslemøy Rolseth (V)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Department of Forensic Sciences, Division of Laboratory Medicine, Oslo University Hospital, N-0424, Oslo, Norway.
ORCID: 0000-0002-6240-7944

Nicolas Kunath (N)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
ORCID: 0000-0002-7641-511X

Rajikala Suganthan (R)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.

Vidar Jensen (V)

GliaLab, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0317, Oslo, Norway.

Anna M Bugaj (AM)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.

Marion S Fernandez-Berrocal (MS)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
ORCID: 0000-0002-5839-9355

Sunniva B Sikko (SB)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
ORCID: 0000-0003-3447-7117

Susanne Vetlesen (S)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.

Anna Kuśnierczyk (A)

Proteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
ORCID: 0000-0003-3517-3481

Ann-Karin Olsen (AK)

Department of Molecular Biology, National Institute of Public Health, N-0456, Oslo, Norway.
Centre of Excellence "Centre for Environmental Radiation" (CERAD), NMBU, N-1433, Ås, Norway.
ORCID: 0000-0003-3982-5213

Kristine B Gützkow (KB)

Department of Molecular Biology, National Institute of Public Health, N-0456, Oslo, Norway.
Centre of Excellence "Centre for Environmental Radiation" (CERAD), NMBU, N-1433, Ås, Norway.

Alexander D Rowe (AD)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Department of Newborn Screening, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, N-0424, Oslo, Norway.

Wei Wang (W)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.

Olve Moldestad (O)

Laboratory of Cellular Neurophysiology and Ion Channel Function, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0317, Oslo, Norway.
Department for Rare Disorders, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, N-0424, Oslo, Norway.

Monica D Syrstad (MD)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.

Geir Slupphaug (G)

Proteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology, N-7491, Trondheim, Norway.

Lars Eide (L)

Department of Medical Biochemistry, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
ORCID: 0000-0003-3948-5183

Arne Klungland (A)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Department of Biosciences, University of Oslo, N-0371, Oslo, Norway.
ORCID: 0000-0001-7274-3661

Pål Sætrom (P)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
ORCID: 0000-0001-8142-7441

Luisa Luna (L)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.

Jing Ye (J)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
ORCID: 0000-0002-6364-4124

Katja Scheffler (K)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
Department of Neurology, University Hospital of Trondheim, N-7006, Trondheim, Norway.

Magnar Bjørås (M)

Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway. magnar.bjoras@ntnu.no.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway. magnar.bjoras@ntnu.no.
ORCID: 0000-0001-8759-1170

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › N-Glycosyl hydrolases › DNA Glycosylases › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Phénomènes psychologiques › Psychologie appliquée › Apprentissage › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › NEIL1 and NEIL2 DNA glycosylases modulate...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › NEIL1 and NEIL2 DNA glycosylases modulate...