Age-Related Expression of IFN-λ1
Adolescent
Adult
Age Factors
Aged
Antiviral Restriction Factors
/ analysis
COVID-19
/ immunology
Cells, Cultured
Female
Humans
Immunity, Innate
/ immunology
Interferon Type I
/ biosynthesis
Interferon-gamma
/ biosynthesis
Interferons
/ biosynthesis
Interleukins
/ biosynthesis
Male
Middle Aged
Nasal Mucosa
/ immunology
Nasopharynx
/ immunology
SARS-CoV-2
/ immunology
Young Adult
beta-Defensins
/ biosynthesis
Interferon Lambda
COVID - 19
IFN - interferon
SARS – CoV – 2
ageing
defensin
mucosal immunity
nasopharyngeal mucosa
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
07
2021
accepted:
26
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
15
12
2021
Statut:
epublish
Résumé
SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities. Children generally remain asymptomatic to primary infection, suggesting that they may have an effective local innate immune response. IFN-I and -III have non-redundant protective roles against SARS-CoV-2, although sometimes damaging the host. The expression and role of anti-viral peptides during SARS-CoV-2 infection have thus far been little studied. We aimed to identify the innate immune molecules present at the SARS-CoV-2 entry point. We analyzed the mRNA levels of type I (IFN-α and -β) and type III (IFN-λ1-3) interferons and selected antiviral peptides (
Identifiants
pubmed: 34858406
doi: 10.3389/fimmu.2021.750279
pmc: PMC8631500
doi:
Substances chimiques
Antiviral Restriction Factors
0
IFNG protein, human
0
interferon-lambda, human
0
Interferon Type I
0
Interleukins
0
beta-Defensins
0
Interferon-gamma
82115-62-6
Interferons
9008-11-1
Interferon Lambda
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
750279Informations de copyright
Copyright © 2021 Gilbert, Lefeuvre, Preisser, Pivert, Soleti, Blanchard, Delneste, Ducancelle, Couez and Jeannin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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