HIF-Dependent
caco-2 cells
cobalt
disease markers
hydroxyquinolines
hypoxia
intestinal bowel disease
transcriptomics
urokinase-type plasminogen activator receptor
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
10
2021
accepted:
27
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory bowel disease (IBD). This work was aimed at studying HIF-associated changes in the intestinal epithelium in IBD. In the first step, a list of genes responding to chemical activation of hypoxia was obtained in an
Identifiants
pubmed: 34858489
doi: 10.3389/fgene.2021.791640
pii: 791640
pmc: PMC8632048
doi:
Types de publication
Journal Article
Langues
eng
Pagination
791640Informations de copyright
Copyright © 2021 Knyazev, Maltseva, Raygorodskaya and Shkurnikov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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