Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia.
Oxidative stress
arterial stiffness
endothelial activation
endothelial dysfunction
peroxynitrite
Journal
Southern African journal of HIV medicine
ISSN: 2078-6751
Titre abrégé: South Afr J HIV Med
Pays: South Africa
ID NLM: 100965417
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
08
2021
accepted:
24
09
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
Cardiovascular disease (CVD) prevalence is rising among persons with HIV (PLWH) in sub-Saharan Africa. Oxidative stress and endothelial activation, resulting in reduced vascular compliance, are contributors to CVD risk. However, there is a paucity of vascular health data in this population. To assess the relationships of oxidative stress and endothelial activation with vascular stiffness among PLWH. Fifty-four PLWH on antiretroviral therapy > 5 years and 57 HIV-negative controls, all aged 18-45 years, were enrolled from the University Teaching Hospital, Lusaka, Zambia. Oxidative stress was measured by nitrotyrosine, a peroxynitrite biomarker, and endothelial activation by soluble intercellular adhesion molecule-1 (sICAM-1) plasma levels. Vascular compliance was measured using carotid-radial pulse wave velocity (crPWV) and arterial stiffness index (crASI). PLWH had higher sICAM-1 levels (median 345 ng/mL) compared to controls (275 ng/mL, PLWH in sub-Saharan Africa had significantly greater oxidative stress and endothelial activation compared to HIV-negative individuals. These factors may contribute to increased arterial stiffness and higher CVD prevalence in this population.
Sections du résumé
BACKGROUND
BACKGROUND
Cardiovascular disease (CVD) prevalence is rising among persons with HIV (PLWH) in sub-Saharan Africa. Oxidative stress and endothelial activation, resulting in reduced vascular compliance, are contributors to CVD risk. However, there is a paucity of vascular health data in this population.
OBJECTIVES
OBJECTIVE
To assess the relationships of oxidative stress and endothelial activation with vascular stiffness among PLWH.
METHOD
METHODS
Fifty-four PLWH on antiretroviral therapy > 5 years and 57 HIV-negative controls, all aged 18-45 years, were enrolled from the University Teaching Hospital, Lusaka, Zambia. Oxidative stress was measured by nitrotyrosine, a peroxynitrite biomarker, and endothelial activation by soluble intercellular adhesion molecule-1 (sICAM-1) plasma levels. Vascular compliance was measured using carotid-radial pulse wave velocity (crPWV) and arterial stiffness index (crASI).
RESULTS
RESULTS
PLWH had higher sICAM-1 levels (median 345 ng/mL) compared to controls (275 ng/mL,
CONCLUSION
CONCLUSIONS
PLWH in sub-Saharan Africa had significantly greater oxidative stress and endothelial activation compared to HIV-negative individuals. These factors may contribute to increased arterial stiffness and higher CVD prevalence in this population.
Identifiants
pubmed: 34858654
doi: 10.4102/sajhivmed.v22i1.1298
pii: HIVMED-22-1298
pmc: PMC8603157
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1298Subventions
Organisme : NIAID NIH HHS
ID : K23 AI100700
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009744
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL130497
Pays : United States
Informations de copyright
© 2021. The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.
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