Glutathione S-Transferase Omega-2 and Transforming Growth Factor-
Journal
Journal of ophthalmology
ISSN: 2090-004X
Titre abrégé: J Ophthalmol
Pays: United States
ID NLM: 101524199
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
06
2021
revised:
21
10
2021
accepted:
08
11
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
To investigate the association of glutathione s-transferase omega 2 (GSTO2) (142N > D) and transforming growth factor- A total of 100 glaucoma patients (60% males and 40% females with an age mean ± SD of 34.66 ± 14.25 years; 56 cases of POAG and 44 cases of CACG) were enrolled in this study. GSTO2 (142N > D) and TGF- At locus GSTO2 (142N > D), the odds of ND genotype with respect to DD and NN genotypes were 1.55 and 2.08 times higher in POAG and CACG patients compared to those of patients in the control group (95% CI The presented results revealed that there was a significant association between the ND genotype of GSTO2 and the pathogenesis of glaucoma. Furthermore, this genotype can be considered as a sex-dependent genetic risk factor for the development of glaucoma. In contrast, the CT genotype of TGF-
Sections du résumé
BACKGROUND
BACKGROUND
To investigate the association of glutathione s-transferase omega 2 (GSTO2) (142N > D) and transforming growth factor-
METHODS
METHODS
A total of 100 glaucoma patients (60% males and 40% females with an age mean ± SD of 34.66 ± 14.25 years; 56 cases of POAG and 44 cases of CACG) were enrolled in this study. GSTO2 (142N > D) and TGF-
RESULTS
RESULTS
At locus GSTO2 (142N > D), the odds of ND genotype with respect to DD and NN genotypes were 1.55 and 2.08 times higher in POAG and CACG patients compared to those of patients in the control group (95% CI
CONCLUSION
CONCLUSIONS
The presented results revealed that there was a significant association between the ND genotype of GSTO2 and the pathogenesis of glaucoma. Furthermore, this genotype can be considered as a sex-dependent genetic risk factor for the development of glaucoma. In contrast, the CT genotype of TGF-
Identifiants
pubmed: 34858663
doi: 10.1155/2021/1061650
pmc: PMC8632431
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1061650Informations de copyright
Copyright © 2021 Shahram Bamdad et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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