Navigation-Guided Transnasal Endoscopic Delineation of the Posterior Margin for Maxillary Sinus Cancers: A Preclinical Study.
3D-virtual endoscopy
intraoperative navigation (NIV)
maxillary sinus cancers
surgical margins
transnasal endoscopic surgery
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
07
2021
accepted:
12
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
The resection of advanced maxillary sinus cancers can be challenging due to the anatomical proximity to surrounding critical anatomical structures. Transnasal endoscopy can effectively aid the delineation of the posterior margin of resection. Implementation with 3D-rendered surgical navigation with virtual endoscopy (3D-SNVE) may represent a step forward. This study aimed to demonstrate and quantify the benefits of this technology. Four maxillary tumor models with critical posterior extension were created in four artificial skulls (Sawbones 3D-SNVE for the transnasal delineation of the posterior margin in maxillary tumor models significantly improved the rate of margin-negative clearance around the tumor and reduced damage to the carotid artery. "Green" cuts occurred in 52.4% in the unguided setting This preclinical study has demonstrated that 3D-SNVE provides a substantial improvement of the posterior margin delineation in terms of safety and oncological adequacy. Translation into the clinical setting, with a meticulous assessment of the oncological outcomes, will be the proposed next step.
Sections du résumé
BACKGROUND
BACKGROUND
The resection of advanced maxillary sinus cancers can be challenging due to the anatomical proximity to surrounding critical anatomical structures. Transnasal endoscopy can effectively aid the delineation of the posterior margin of resection. Implementation with 3D-rendered surgical navigation with virtual endoscopy (3D-SNVE) may represent a step forward. This study aimed to demonstrate and quantify the benefits of this technology.
MATERIAL AND METHOD
METHODS
Four maxillary tumor models with critical posterior extension were created in four artificial skulls (Sawbones
RESULTS
RESULTS
3D-SNVE for the transnasal delineation of the posterior margin in maxillary tumor models significantly improved the rate of margin-negative clearance around the tumor and reduced damage to the carotid artery. "Green" cuts occurred in 52.4% in the unguided setting
CONCLUSIONS
CONCLUSIONS
This preclinical study has demonstrated that 3D-SNVE provides a substantial improvement of the posterior margin delineation in terms of safety and oncological adequacy. Translation into the clinical setting, with a meticulous assessment of the oncological outcomes, will be the proposed next step.
Identifiants
pubmed: 34858824
doi: 10.3389/fonc.2021.747227
pmc: PMC8632239
doi:
Types de publication
Journal Article
Langues
eng
Pagination
747227Informations de copyright
Copyright © 2021 Taboni, Ferrari, Daly, Chan, Eu, Gualtieri, Jethwa, Sahovaler, Sewell, Hasan, Berania, Qiu, de Almeida, Nicolai, Gilbert and Irish.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Arch Otolaryngol Head Neck Surg. 2009 Dec;135(12):1219-24
pubmed: 20026819
Laryngoscope. 2020 May;130(5):1166-1172
pubmed: 31112320
Rhinol Suppl. 2010 Jun 01;22:1-143
pubmed: 20502772
Otolaryngol Head Neck Surg. 2015 Aug;153(2):231-8
pubmed: 26044790
PLoS One. 2017 Mar 1;12(3):e0173111
pubmed: 28249001
Oral Oncol. 2009 Aug;45(8):720-6
pubmed: 19103507
J Craniomaxillofac Surg. 2010 Dec;38(8):589-94
pubmed: 20381368
Head Neck. 2012 Nov;34(11):1652-6
pubmed: 22252962
Oral Oncol. 2019 Dec;99:104463
pubmed: 31683173
Cancer. 1998 Aug 1;83(3):457-65
pubmed: 9690538
Int J Comput Assist Radiol Surg. 2017 May;12(5):881-887
pubmed: 27659282
Med Phys. 2006 Oct;33(10):3767-80
pubmed: 17089842
Rhinology. 2003 Mar;41(1):44-8
pubmed: 12677740
World Neurosurg. 2014 Dec;82(6 Suppl):S22-31
pubmed: 25496631
Oral Oncol. 2020 Jul;106:104672
pubmed: 32298995
Comput Aided Surg. 2000;5(5):343-52
pubmed: 11169880
Eur J Surg Oncol. 2008 Jun;34(6):699-703
pubmed: 18029135
Br J Oral Maxillofac Surg. 2015 Nov;53(9):814-9
pubmed: 26212419
J Craniofac Surg. 2008 Jul;19(4):1067-74
pubmed: 18650734
J Bone Joint Surg Am. 2015 Jan 7;97(1):40-6
pubmed: 25568393
J Neurol Surg B Skull Base. 2016 Aug;77(4):364-70
pubmed: 27441163
J Neurooncol. 2020 Dec;150(3):405-417
pubmed: 31897925
J Digit Imaging. 2007 Nov;20 Suppl 1:21-33
pubmed: 17703338
Otolaryngol Clin North Am. 2017 Jun;50(3):617-632
pubmed: 28392037
J Surg Oncol. 2008 Jun 15;97(8):658-64
pubmed: 18493946
Am J Rhinol. 2008 May-Jun;22(3):308-16
pubmed: 18588765
Keio J Med. 2009 Sep;58(3):152-60
pubmed: 19826209
Otolaryngol Clin North Am. 2016 Feb;49(1):183-200
pubmed: 26614837
J Craniomaxillofac Surg. 2017 Dec;45(12):2109-2114
pubmed: 29092758
J Craniomaxillofac Surg. 2018 Dec;46(12):2240-2247
pubmed: 30482714
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):719-30
pubmed: 17543999
Am J Rhinol Allergy. 2010 Jan-Feb;24(1):60-5
pubmed: 20109329
Adv Ther. 2017 Oct;34(10):2181-2198
pubmed: 28871554
J Oral Maxillofac Surg. 2017 Sep;75(9):1987-2005
pubmed: 28193444
Head Neck. 2013 Jul;35(7):959-67
pubmed: 22791312
Rhinology. 2015 Sep;53(3):204-11
pubmed: 26363161
J Oral Maxillofac Surg. 2009 Jun;67(6):1197-205
pubmed: 19446204
Laryngoscope. 2014 Apr;124(4):853-9
pubmed: 24122916
Oral Oncol. 2019 Jun;93:29-38
pubmed: 31109693
J Biomed Opt. 2013 Aug;18(8):86007
pubmed: 23942632
J Craniofac Surg. 2015 Mar;26(2):e126-32
pubmed: 25710743
Med Phys. 2005 Jan;32(1):241-54
pubmed: 15719975
Curr Oncol Rep. 2011 Apr;13(2):138-44
pubmed: 21243539
Am J Rhinol. 2007 Jan-Feb;21(1):89-94
pubmed: 17283568
Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Dec;133(6):405-411
pubmed: 27386803