Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells.
actomyosin
adherens junction
contact inhibition
epidermoid carcinoma
mechanosensing
mechanotransduction
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
06
2021
accepted:
19
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
Actomyosin contractility regulates various cellular processes including proliferation and differentiation while dysregulation of actomyosin activity contributes to cancer development and progression. Previously, we have reported that actomyosin-generated tension at adherens junctions is required for cell density-dependent inhibition of proliferation of normal skin keratinocytes. However, it remains unclear how actomyosin contractility affects the hyperproliferation ability of cutaneous squamous cell carcinoma (cSCC) cells. In this study, we find that actomyosin activity is impaired in cSCC cells both
Identifiants
pubmed: 34858971
doi: 10.3389/fcell.2021.728383
pii: 728383
pmc: PMC8632149
doi:
Types de publication
Journal Article
Langues
eng
Pagination
728383Informations de copyright
Copyright © 2021 Dobrokhotov, Sunagawa, Torii, Mii, Kawauchi, Enomoto, Sokabe and Hirata.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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