NMR Studies of Tau Protein in Tauopathies.
Alzheimer’s disease
filaments
nuclear magnetic resonance
protein structure
tau
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
08
2021
accepted:
25
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
Tauopathies, including Alzheimer's disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has become an appealing target for therapy. Current knowledge of the pathological effects and significance of specific species in the tau aggregation pathway is incomplete although more and more structural and mechanistic insights are being gained using biophysical techniques. Here, we review the application of NMR to structural studies of various tau forms that appear in its aggregation process, focusing on results obtained from solid-state NMR. Furthermore, we discuss implications from these studies and their prospective contribution to the development of new tauopathy therapies.
Identifiants
pubmed: 34859051
doi: 10.3389/fmolb.2021.761227
pii: 761227
pmc: PMC8632555
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
761227Informations de copyright
Copyright © 2021 Kitoka, Skrabana, Gasparik, Hritz and Jaudzems.
Déclaration de conflit d'intérêts
Author RS was employed by AXON Neuroscience R&D Services SE. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Science. 2018 Jun 15;360(6394):1242-1246
pubmed: 29748322
Proc Natl Acad Sci U S A. 1988 Jun;85(11):4051-5
pubmed: 3131773
Biochemistry. 2005 Jan 25;44(3):1026-36
pubmed: 15654759
Chem Rev. 2014 Jul 9;114(13):6561-88
pubmed: 24739139
J Am Chem Soc. 2005 Jul 27;127(29):10138-9
pubmed: 16028903
Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6819-23
pubmed: 25881502
Biochemistry. 2020 Jun 23;59(24):2237-2248
pubmed: 32453948
Biochemistry. 1999 Mar 23;38(12):3549-58
pubmed: 10090741
J Neuroinflammation. 2012 Mar 07;9:47
pubmed: 22397366
Biophys Chem. 2017 Apr;223:25-29
pubmed: 28282625
Biochemistry. 2006 May 2;45(17):5527-37
pubmed: 16634634
J Am Chem Soc. 2021 May 26;143(20):7839-7851
pubmed: 33983722
Biochemistry. 2008 Oct 14;47(41):10841-51
pubmed: 18803399
J Biol Chem. 1984 Apr 25;259(8):5301-5
pubmed: 6425287
Int J Mol Sci. 2018 Dec 26;20(1):
pubmed: 30587819
Acta Neuropathol Commun. 2017 Nov 29;5(1):91
pubmed: 29187252
Nat Chem. 2017 Sep;9(9):874-881
pubmed: 28837163
Nature. 2018 Sep;561(7721):137-140
pubmed: 30158706
J Biol Chem. 2020 Jun 5;295(23):7905-7922
pubmed: 32341125
Nature. 2017 Jul 13;547(7662):185-190
pubmed: 28678775
FEBS Lett. 2009 Sep 3;583(17):2739-42
pubmed: 19647741
J Am Chem Soc. 2013 Feb 20;135(7):2853-62
pubmed: 23360400
J Biol Chem. 2011 Jun 10;286(23):20512-24
pubmed: 21498513
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6923-8
pubmed: 11381127
Biochemistry. 2008 Jul 15;47(28):7393-404
pubmed: 18558718
J Am Chem Soc. 2010 Sep 1;132(34):11906-7
pubmed: 20687558
Chembiochem. 2005 Oct;6(10):1849-56
pubmed: 16196016
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Biochem Biophys Res Commun. 2011 Sep 9;412(4):743-6
pubmed: 21871442
J Mol Biol. 2017 Nov 24;429(23):3650-3665
pubmed: 28919235
Int J Geriatr Psychiatry. 2011 Aug;26(8):825-32
pubmed: 21744385
PLoS One. 2016 Aug 22;11(8):e0160635
pubmed: 27548710
Acc Chem Res. 2018 Jun 19;51(6):1550-1557
pubmed: 29869502
Neuron. 1993 Jul;11(1):153-63
pubmed: 8393323
Prog Mol Biol Transl Sci. 2019;166:19-61
pubmed: 31521232
Nat Rev Neurol. 2011 Mar;7(3):137-52
pubmed: 21304480
Protein Sci. 2016 May;25(5):1010-20
pubmed: 26940799
J Biomol NMR. 2014 Feb;58(2):129-39
pubmed: 24435565
Neurosci Lett. 2004 Mar 4;357(2):143-6
pubmed: 15036595
J Magn Reson. 2013 Jul;232:18-30
pubmed: 23685715
Biochem Biophys Res Commun. 2006 Sep 22;348(2):637-42
pubmed: 16889747
Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11520-4
pubmed: 21990182
Phys Chem Chem Phys. 2014 May 7;16(17):7710-7
pubmed: 24448233
Nat Commun. 2021 Mar 15;12(1):1677
pubmed: 33723253
PLoS One. 2012;7(4):e34679
pubmed: 22529924
J Biol Chem. 1999 Mar 19;274(12):8029-38
pubmed: 10075702
J Biol Chem. 2020 May 22;295(21):7470-7480
pubmed: 32291284
Chembiochem. 2004 Jan 3;5(1):73-8
pubmed: 14695515
Acta Neuropathol. 2004 Oct;108(4):279-86
pubmed: 15235803
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34
pubmed: 10805776
FASEB J. 2015 Oct;29(10):4133-44
pubmed: 26103986
J Biol Chem. 2007 Apr 20;282(16):12230-9
pubmed: 17307736
Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9080-9085
pubmed: 28784767
Nature. 2016 Aug 31;537(7618):50-6
pubmed: 27582220
Eur J Biochem. 2004 Feb;271(3):545-52
pubmed: 14728681
Nature. 2016 Feb 4;530(7588):45-50
pubmed: 26808899
Proteins. 2003 Nov 1;53(2):220-8
pubmed: 14517973
FASEB J. 2012 May;26(5):1946-59
pubmed: 22253473
Alzheimers Res Ther. 2014 Jul 03;6(4):37
pubmed: 25024750
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11335-40
pubmed: 25049396
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7501-6
pubmed: 26034266
J Biol Chem. 2005 Jul 1;280(26):24978-86
pubmed: 15855160
J Am Chem Soc. 2008 May 7;130(18):5922-8
pubmed: 18386894
ACS Chem Neurosci. 2018 Nov 21;9(11):2639-2654
pubmed: 29722962
J Biol Chem. 1993 Jan 15;268(2):1166-73
pubmed: 8419321
Biochemistry. 2000 Aug 1;39(30):9039-46
pubmed: 10913317
Neuropathol Appl Neurobiol. 2015 Feb;41(1):3-23
pubmed: 25495175
EMBO J. 2017 Nov 2;36(21):3120-3138
pubmed: 28864542
Nat Commun. 2021 Jul 9;12(1):4231
pubmed: 34244499
Elife. 2019 Feb 05;8:
pubmed: 30720432
Acta Neuropathol Commun. 2019 Feb 15;7(1):22
pubmed: 30767766
Chem Commun (Camb). 2018 May 1;54(36):4573-4576
pubmed: 29664486
Angew Chem Int Ed Engl. 2020 Jan 27;59(5):1818-1827
pubmed: 31692167
J Mol Biol. 2016 Jan 16;428(1):79-91
pubmed: 26655856
J Alzheimers Dis. 2018;64(s1):S535-S546
pubmed: 29865059
Nat Rev Neurol. 2018 Jul;14(7):399-415
pubmed: 29895964
Protein Sci. 2006 Dec;15(12):2795-804
pubmed: 17088319
J Neurosci. 2007 Apr 4;27(14):3650-62
pubmed: 17409229
J Mol Neurosci. 2019 Aug;68(4):620-630
pubmed: 31062171
J Biol Chem. 2000 Aug 18;275(33):25247-54
pubmed: 10840038
J Biol Chem. 2016 Apr 1;291(14):7742-53
pubmed: 26858248
J Am Chem Soc. 2012 Aug 29;134(34):13982-9
pubmed: 22862303
Biochemistry. 2007 Mar 20;46(11):3055-64
pubmed: 17311412
J Am Chem Soc. 2006 Mar 22;128(11):3575-83
pubmed: 16536530
Biochemistry. 2009 Oct 27;48(42):10047-55
pubmed: 19769346
FEBS Lett. 2010 Oct 8;584(19):4233-6
pubmed: 20837015
Biopolymers. 2014 May;102(3):288-95
pubmed: 24687309
Sci Rep. 2020 Dec 3;10(1):21210
pubmed: 33273615
J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9
pubmed: 22002422
PLoS Biol. 2009 Feb 17;7(2):e34
pubmed: 19226187
FASEB J. 2009 Apr;23(4):1146-52
pubmed: 19074508
Front Neurosci. 2018 Nov 02;12:798
pubmed: 30450030
Biochem Biophys Res Commun. 2009 May 22;383(1):37-41
pubmed: 19324008
Chembiochem. 2004 Dec 3;5(12):1639-46
pubmed: 15532033
Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3246-3250
pubmed: 29314492
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5819-24
pubmed: 21421841
ACS Omega. 2019 Mar 31;4(3):5356-5366
pubmed: 31001602
Biochem Biophys Res Commun. 2014 Mar 7;445(2):299-303
pubmed: 24502945
Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16357-16366
pubmed: 31358628
J Biochem. 2005 Oct;138(4):413-23
pubmed: 16272135
Biochem Biophys Res Commun. 2021 May 21;554:145-150
pubmed: 33798940
Structure. 2015 Aug 4;23(8):1448-1458
pubmed: 26165593
J Mol Biol. 1995 Jan 13;245(2):180-94
pubmed: 7799434
Proteins. 2012 Feb;80(2):454-62
pubmed: 22072628
Chemistry. 2017 Dec 1;23(67):16976-16979
pubmed: 29044752
Biochem Biophys Res Commun. 2002 Jun 7;294(2):210-4
pubmed: 12051695
Protein Pept Lett. 2006;13(3):235-46
pubmed: 16515451
Biomolecules. 2019 Mar 16;9(3):
pubmed: 30884818
ACS Chem Biol. 2019 Jun 21;14(6):1363-1379
pubmed: 31046227
Cell Rep. 2021 Mar 16;34(11):108843
pubmed: 33730588
Chembiochem. 2021 Jun 15;22(12):2093-2097
pubmed: 33826208
Angew Chem Int Ed Engl. 2020 Mar 2;59(10):4059-4067
pubmed: 31863676
Neurosci Lett. 1996 May 3;209(1):57-60
pubmed: 8734909
Biochemistry. 2007 Mar 13;46(10):2574-82
pubmed: 17297915
J Am Chem Soc. 2017 Feb 22;139(7):2639-2646
pubmed: 28124562
Nature. 2020 Apr;580(7802):283-287
pubmed: 32050258
Curr Opin Neurobiol. 2021 Aug;69:131-138
pubmed: 33892381
Biochim Biophys Acta. 2005 Jan 3;1739(2-3):158-66
pubmed: 15615635
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8463-7
pubmed: 7667312
Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10347-51
pubmed: 26094605
Biochemistry. 2006 Oct 17;45(41):12560-72
pubmed: 17029411
Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1953-8
pubmed: 16446437
Biochemistry. 2001 Dec 4;40(48):14317-23
pubmed: 11724542
Protein Sci. 2018 Nov;27(11):1901-1909
pubmed: 30125425
FEBS Lett. 2020 Mar;594(5):944-950
pubmed: 31721178
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4884-8
pubmed: 2455299
Nature. 1996 Oct 10;383(6600):550-3
pubmed: 8849730
J Am Chem Soc. 2018 Jul 5;140(26):8138-8146
pubmed: 29708745
Biochemistry. 2013 Sep 17;52(37):6445-55
pubmed: 23962087
Nature. 2010 Apr 22;464(7292):1201-4
pubmed: 20357768