The use of nondirected donor organs in living donor liver transplantation: Perspectives and guidance.


Journal

Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946

Informations de publication

Date de publication:
06 2022
Historique:
revised: 04 11 2021
received: 27 07 2021
accepted: 05 11 2021
pubmed: 4 12 2021
medline: 20 5 2022
entrez: 3 12 2021
Statut: ppublish

Résumé

Interest in anonymous nondirected living organ donation is increasing in the United States and a small number of transplantation centers are accumulating an experience regarding nondirected donation in living donor liver transplantation. Herein, we review current transplant policy, discuss emerging data, draw parallels from nondirected kidney donation, and examine relevant considerations in nondirected living liver donation. We aim to provide a consensus guidance to ensure safe evaluation and selection of nondirected living liver donors and a schema for just allocation of nondirected grafts.

Identifiants

pubmed: 34859474
doi: 10.1002/hep.32260
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1579-1589

Informations de copyright

© 2021 American Association for the Study of Liver Diseases.

Références

Shah SA, Levy GA, Greig PD, Smith R, McGilvray ID, Lilly LB, et al. Reduced mortality with right-lobe living donor compared to deceased-donor liver transplantation when analyzed from the time of listing. Am J Transplant. 2007;7(4):998-1002.
Nicolas CT, Nyberg SL, Heimbach JK, Watt K, Chen HS, Hathcock MA, et al. Liver transplantation after share 35: impact on pretransplant and posttransplant costs and mortality. Liver Transpl. 2017;23(1):11-8.
Leung DH, Narang A, Minard CG, Hiremath G, Goss JA, Shepherd R. A 10-year united network for organ sharing review of mortality and risk factors in young children awaiting liver transplantation. Liver Transpl. 2016;22(11):1584-92.
Goldberg DS, French B, Lewis JD, Scott FI, Mamtani R, Gilroy R, et al. Liver transplant center variability in accepting organ offers and its impact on patient survival. J Hepatol. 2016;64(4):843-51.
Abu-Gazala S, Olthoff KM. Current status of living donor liver transplantation in the United States. Annu Rev Med. 2019;70:225-38.
Lauterio A, Di Sandro S, Gruttadauria S, Spada M, Di Benedetto F, Baccarani U, et al. Donor safety in living donor liver donation: an Italian multicenter survey. Liver Transpl. 2017;23(2):184-93.
Goldaracena N, Jung J, Aravinthan AD, Abbey SE, Krause S, Pritlove C, et al. Donor outcomes in anonymous live liver donation. J Hepatol. 2019;71(5):951-9.
Berg CL, Merion RM, Shearon TH, Olthoff KM, Brown RS, Baker TB, et al. Liver transplant recipient survival benefit with living donation in the Model for Endstage Liver Disease allocation era. Hepatology. 2011;54(4):1313-21.
Berg CL, Gillespie BW, Merion RM, Brown RS, Abecassis MM, Trotter JF, et al. Improvement in survival associated with adult-to-adult living donor liver transplantation. Gastroenterology. 2007;133(6):1806-13.
Barbetta A, Aljehani M, Kim M, Tien C, Ahearn A, Schilperoort H, et al. Meta-analysis and meta-regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation. Am J Transplant. 2021;21(7):2399-412.
Dew MA, DiMartini AF, Ladner DP, Simpson MA, Pomfret EA, Gillespie BW, et al. Psychosocial outcomes 3 to 10 years after donation in the adult to adult living donor liver transplantation cohort study. Transplantation. 2016;100(6):1257-69.
National data. Organ Procurement and Transplantation Network. 2020. https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/. Accessed 1 Nov 2021.
Hunt HF, Rodrigue JR, Dew MA, Schaffer RL, Henderson ML, Bloom R, et al. Strategies for increasing knowledge, communication, and access to living donor transplantation: an evidence review to inform patient education. Curr Transplant Rep. 2018;5(1):27-44.
Park A. UPMC's campaign for living-donor liver transplants resulted in 20,000 inquiries in its 1st year - 2 marketing leaders explain how. Becker's Hospital Review. November 20, 2019. https://www.beckershospitalreview.com/digital-marketing/upmc-s-campaign-for-living-donor-liver-transplants-resulted-in-20-000-inquiries-in-its-1st-year-2-marketing-leaders-explain-how.html. Accessed 1 Nov 2021.
Living non-directed organ donation. Organ Procurement and Transplantation Network. December 2015. Accessed 11 Oct 2020. https://optn.transplant.hrsa.gov/resources/ethics/living-non-directed-organ-donation/.
Gare R, Gogalniceanu P, Maple H, Burnapp L, Clarke A, Williams L, et al. Understanding barriers and outcomes of unspecified (non-directed altruistic) kidney donation from both professional's and patient's perspectives: research protocol for a national multicentre mixed-methods prospective cohort study. BMJ Open. 2017;7(9):e015971.
Organ Procurement and Transplantation Network. Policy 14: Living donation. October 7, 2021. https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf. Accessed 1 Nov 2021.
Wright L, Ross K, Abbey S, Levy G, Grant D. Living anonymous liver donation: case report and ethical justification. Am J Transplant. 2007;7(4):1032-5.
Reichman TW, Fox A, Adcock L, Wright L, Abbey SE, Levy G, et al. Anonymous living liver donation: donor profiles and outcomes. Am J Transplant. 2010;10(9):2099-104.
Jendrisak MD, Hong B, Shenoy S, Lowell J, Desai N, Chapman W, et al. Altruistic living donors: evaluation for nondirected kidney or liver donation. Am J Transplant. 2006;6(1):115-20.
Jean-Bernard O. Good Samaritan liver donor in pediatric transplantation. Pediatr Transplant. 2009;13(2):155-9.
Raza MH, Aziz H, Kaur N, Lo M, Sher L, Genyk Y, et al. Global experience and perspective on anonymous nondirected live donation in living donor liver transplantation. Clin Transplant. 2020;34(4):e13836.
Pruett TL, Tibell A, Alabdulkareem A, Bhandari M, Cronin DC, Dew MA, et al. The ethics statement of the Vancouver Forum on the live lung, liver, pancreas, and intestine donor. Transplantation. 2006;81(10):1386-7.
Raza MH, Jackson WE, Dell A, Ding LI, Shapiro J, Pomfret EA, et al. Health-related quality of life after anonymous nondirected living liver donation: a multicenter collaboration. Am J Transplant. 2021;21(3):1056-67.
Nair A, Modaresi Esfeh J, Kwon CHD, Aucejo F, Quintini C, Hashimoto K. Living liver donation in previous kidney donors: a single-center experience. Am J Transplant. 2020;20(5):1461-2.
Jackson WE, Kriss MS, Burton JR, Nydam TL, Conzen KD, Pomposelli JJ, et al. Reply to “Living liver donation in previous kidney donors: a single-center experience”. Am J Transplant. 2021;21(1):435-7.
Braun HJ, Torres AM, Louie F, Weinberg SD, Kang S-M, Ascher NL, et al. Expanding living donor liver transplantation: report of first US living donor liver transplant chain. Am J Transplant. 2021;21(4):1633-6.
Baker TB. Living liver donation, donor safety, and social media: preparing for a new frontier. Liver Transpl. 2017;23(2):131-2.
Melcher ML, Veale JL, Javaid B, Leeser DB, Davis CL, Hil G, et al. Kidney transplant chains amplify benefit of nondirected donors. JAMA Surg. 2013;148(2):165-9.
Adams PL, Cohen DJ, Danovitch GM, Edington RMD, Gaston RS, Jacobs CL, et al. The nondirected live-kidney donor: ethical considerations and practice guidelines: a National Conference Report. Transplantation. 2002;74(4):582-9.
Tong A, Craig JC, Wong G, Morton J, Armstrong S, Schollum J, et al. “It was just an unconditional gift.” Self reflections of non-directed living kidney donors. Clin Transplant. 2012;26(4):589-99.
Tong A, Chapman JR, Wong G, Kanellis J, McCarthy G, Craig JC. The motivations and experiences of living kidney donors: a thematic synthesis. Am J Kidney Dis. 2012;60(1):15-26.
Segev DL, Montgomery RA. Regional and racial disparities in the use of live non-directed kidney donors. Am J Transplant. 2008;8(5):1051-5.
Rodrigue JR, Widows MR, Guenther R, Newman RC, Kaplan B, Howard RJ. The expectancies of living kidney donors: do they differ as a function of relational status and gender? Nephrol Dial Transplant. 2006;21(6):1682-8.
Wong TCL, Fung JYY, Pang HH, Leung CK, Li HF, Sin SL, et al. Analysis of survival benefits of living vs. deceased donor liver transplant in high MELD and hepatorenal syndrome. Hepatology. 2021;73(6):2441-54.
Urrunaga NH, Rachakonda VP, Magder LS, Mindikoglu AL. Outcomes of living versus deceased donor liver transplantation for acute liver failure in the United States. Transplant Proc. 2014;46(1):219-24.
Rudow LD, Warburton KM. Selection and postoperative care of the living donor. Med Clin North Am. 2016;100(3):599-611.
Trotter JF. Selection of donors for living donor liver transplantation. Liver Transpl. 2003;9(10 Suppl 2):S2-7.
Trotter JF, Wisniewski KA, Terrault NA, Everhart JE, Kinkhabwala M, Weinrieb RM, et al. Outcomes of donor evaluation in adult-to-adult living donor liver transplantation. Hepatology. 2007;46(5):1476-84.
Samstein B, Griesemer A, Cherqui D, Mansour T, Pisa J, Yegiants A, et al. Fully laparoscopic left-sided donor hepatectomy is safe and associated with shorter hospital stay and earlier return to work: a comparative study. Liver Transpl. 2015;21(6):768-73.
Broering DC, Elsheikh Y, Alnemary Y, Zidan A, Elsarawy A, Saleh Y, et al. Robotic versus open right lobe donor hepatectomy for adult living donor liver transplantation: a propensity score-matched analysis. Liver Transpl. 2020;26(11):1455-64.
Rho SY, Lee JG, Joo DJ, Kim MS, Kim SI, Han DH, et al. Outcomes of robotic living donor right hepatectomy from 52 consecutive cases: comparison with open and laparoscopy-assisted donor hepatectomy. Ann Surg. 2020 July 8. https://doi.org/10.1097/SLA.0000000000004067. [Epub ahead of print]
Dew MA, Jacobs CL, Jowsey SG, Hanto R, Miller C, Delmonico FL, et al. Guidelines for the psychosocial evaluation of living unrelated kidney donors in the United States. Am J Transplant. 2007;7(5):1047-54.
Papachristou C, Walter M, Dietrich K, Danzer G, Klupp J, Klapp BF, et al. Motivation for living-donor liver transplantation from the donor's perspective: an in-depth qualitative research study. Transplantation. 2004;78(10):1506-14.
Maghen A, Vargas GB, Connor SE, Nassiri S, Hicks EM, Kwan L, et al. Spirituality and religiosity of non-directed (altruistic) living kidney donors. J Clin Nurs. 2018;27(7-8):1662-72.
Simpson MA, Kendrick J, Verbesey JE, Morin DS, Amanda Dew M, Trabucco A, et al. Ambivalence in living liver donors. Liver Transpl. 2011;17(10):1226-33.
Potts S, Vitinius F, Erim Y, Gazdag G, Gribble R, Ismail SY, et al. Mental health assessment of altruistic non-directed kidney donors: an EAPM consensus statement. J Psychosom Res. 2018;107:26-32.
Kook YWA, Shenoy A, Hunt J, Desrosiers F, Gordon-Elliott JS, Jowsey-Gregoire S, et al. Multicenter investigation of the reliability and validity of the live donor assessment tool as an enhancement to the psychosocial evaluation of living donors. Am J Transplant. 2019;19(4):1119-28.
Papachristou C, Walter M, Frommer J, Klapp BF. Decision-making and risk-assessment in living liver donation: how informed is the informed consent of donors? A qualitative study. Psychosomatics. 2010;51(4):312-9.
Shenoy A. The psychosocial evaluation of live donors. In: Sher Y, Maldonado JR, eds. Psychosocial care of end-stage organ disease and transplant patients. 1st ed. Springer; 2019:49-62.
Timmerman L, Laging M, Westerhof GJ, Timman R, Zuidema WC, Beck DK, et al. Mental health among living kidney donors: a prospective comparison with matched controls from the general population. Am J Transplant. 2015;15(2):508-17.
Butt Z, Dew MA, Liu Q, Simpson MA, Smith AR, Zee J, et al. Psychological outcomes of living liver donors from a multicenter prospective study: results from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A2ALL-2). Am J Transplant. 2017;17(5):1267-77.
Kasiske BL, Ahn YS, Conboy M, Dew MA, Folken C, Levan M, et al. Outcomes of living kidney donor candidate evaluations in the living donor collective pilot registry. Transplant Direct. 2021;7(5):e689.
Fortin MC, Dion-Labrie M, Hébert MJ, Achille M, Doucet H. Are ‘anonymous’ and ‘non-directed’ prerequisites for living altruistic donation? The views of transplant physicians from France and Québec. Soc Sci Med 1982. 2008;67(1):147-51.
Procurement O, Network T. Health resources and services administration, HHS. Final rule. Fed Regist. 1999;64(202):56650-61.
Bentham J. An introduction to the principles of morals and legislation. London: Oxford University Press; 1970.
Mill JS. Utilitarianism. London: Parker, Son & Bourn; 1863.
Organ Procurement and Transplantation Network. Policy 9: allocation of livers and liver-intestines. 2021. https://optn.transplant.hrsa.gov/media/eavh5bf3/optn_policies.pdf. Accessed 1 Nov 2021.
Selzner M, Kashfi A, Cattral MS, Selzner N, McGilvray ID, Greig PD, et al. Live donor liver transplantation in high MELD score recipients. Ann Surg. 2010;251(1):153-57.
Alexander S. They decide who lives, who dies: medical miracle and a moral burden of a small committee. Life. 1962;19:102-25.
Rawls J. A theory of justice. Cambridge, MA: Harvard University Press; 1971.
Rawls J. Justice as fairness: a restatement. Cambridge, MA: Harvard University Press; 2001.
Batra RK. Utility of liver transplantation within the bounds of non-futility. Curr Transpl Rep. 2020;7(3):187-93.
Llovet JM, Pavel M, Rimola J, Diaz MA, Colmenero J, Saavedra-Perez D, et al. Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria). Liver Transpl. 2018;24(3):369-79.
Lerut J, Iesari S, Vandeplas G, Fabbrizio T, Ackenine K, Núñez MEI, et al. Secondary non-resectable liver tumors: a single-center living-donor and deceased-donor liver transplantation case series. Hepatobiliary Pancreat Dis Int. 2019;18(5):412-22.
Hafeez Bhatti AB, Tahir R, Qureshi NR, Mamoon N, Khan NY, Zia HH. Living donor liver transplantation for intra hepatic cholangiocarcinoma. Ann Med Surg (Lond). 2020;57:82-4.
Chang CC, Chen YJ, Huang TH, Chen C-H, Kuo F-Y, Eng H-L, et al. Living donor liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: experience of a single center. Ann Transplant. 2017;22:115-20.
Halazun KJ, Przybyszewski EM, Griesemer AD, Cherqui D, Michelassi F, Guarrera JV, et al. Leaning to the left: increasing the donor pool by using the left lobe, outcomes of the largest single-center North American experience of left lobe adult-to-adult living donor liver transplantation. Ann Surg. 2016;264(3):448-56.
Kwong AJ, Kim WR, Lake JR, Smith JM, Schladt DP, Skeans MA, et al. OPTN/SRTR 2019 annual data report: liver. Am J Transplant. 2021;21(Suppl 2):208-315.
Locke JE, Shelton BA, Olthoff KM, Pomfret EA, Forde KA, Sawinski D, et al. Quantifying sex-based disparities in liver allocation. JAMA Surg. 2020;155(7):e201129.
Allen AM, Heimbach JK, Larson JJ, Mara KC, Kim WR, Kamath PS, et al. Reduced access to liver transplantation in women: role of height, MELD exception scores, and renal function underestimation. Transplantation. 2018;102(10):1710-6.

Auteurs

Alyson N Fox (AN)

Columbia University Irving Medical Center (CUIMC) Center for Liver Disease and Transplanation NY Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

AnnMarie Liapakis (A)

Yale-New Haven Health Transplanation Center, Yale University School of Medicine, New Haven, Connecticut, USA.

Ramesh Batra (R)

Yale-New Haven Health Transplanation Center, Yale University School of Medicine, New Haven, Connecticut, USA.

Therese Bittermann (T)

Penn Transplant Institute, Penn Medicine, Perelman School of Medicine Unniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.

Juliet Emamaullee (J)

University of Southern California (USC) Transplant Institute, Keck School of Medicine of USC, Los Angeles, California, USA.

Sukru Emre (S)

Yale-New Haven Health Transplanation Center, Yale University School of Medicine, New Haven, Connecticut, USA.

Yuri Genyk (Y)

University of Southern California (USC) Transplant Institute, Keck School of Medicine of USC, Los Angeles, California, USA.

Hyosun Han (H)

University of Southern California (USC) Transplant Institute, Keck School of Medicine of USC, Los Angeles, California, USA.

Whitney Jackson (W)

Colorado Center for Transplantation Care, Research and Education, University of Colorado School of Medicine, Aurora, Colorado, USA.

Elizabeth Pomfret (E)

Colorado Center for Transplantation Care, Research and Education, University of Colorado School of Medicine, Aurora, Colorado, USA.

Muhammad Raza (M)

Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Manuel Rodriguez-Davalos (M)

Intermountain Transplant Center, Primary Children's Hospital, Salt Lake City, Utah, USA.

Susan Rubman Gold (S)

Yale-New Haven Health Transplanation Center, Yale University School of Medicine, New Haven, Connecticut, USA.

Benjamin Samstein (B)

Weill Cornell Medicine Center for Liver Disease and Transplantation NY Presbyterian Hospital, Weill Cornell School of Medicine, New York, New York, USA.

Akhil Shenoy (A)

Columbia University Irving Medical Center (CUIMC) Center for Liver Disease and Transplanation NY Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Timucin Taner (T)

Mayo Clinic Transplant Center, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

John P Roberts (JP)

Organ Transplant Program, University of California San Francisco (UCSF) Health, UCSF School of Medicine, San Francisco, California, USA.

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