Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance.
pituitary
thyroid
thyroid hormone receptor
thyroid hormone resistance
Journal
Endocrine connections
ISSN: 2049-3614
Titre abrégé: Endocr Connect
Pays: England
ID NLM: 101598413
Informations de publication
Date de publication:
19 01 2022
19 01 2022
Historique:
received:
23
11
2021
accepted:
03
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
entrez:
3
12
2021
Statut:
epublish
Résumé
Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone receptor β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly expressing the β form of the receptor (pituitary, liver). This study seeks to identify the effects of mutant TRβ on pituitary size. High-resolution 3D T1-weighted magnetic resonance images were acquired in 19 patients with RTHβ in comparison to 19 healthy matched controls. Volumetric measurements of the pituitary gland were performed independently and blinded by four different raters (two neuroradiologists, one neurologist, one neuroscientist). Patients with mutant TRβ (resistance to thyroid hormone β, RTHβ) showed elevated free tri-iodothyronine/thyroxine levels with normal thyroid-stimulating hormone levels, whereas healthy controls showed normal thyroid hormone levels. Imaging revealed smaller pituitary size in RTHβ patients in comparison to healthy controls (F(1,35) = 7.05, P = 0.012, partial η2 = 0.17). RTHβ subjects have impaired sensitivity to thyroid hormones, along with decreased size of the pituitary gland.
Sections du résumé
Background
Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone receptor β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly expressing the β form of the receptor (pituitary, liver). This study seeks to identify the effects of mutant TRβ on pituitary size.
Methods
High-resolution 3D T1-weighted magnetic resonance images were acquired in 19 patients with RTHβ in comparison to 19 healthy matched controls. Volumetric measurements of the pituitary gland were performed independently and blinded by four different raters (two neuroradiologists, one neurologist, one neuroscientist).
Results
Patients with mutant TRβ (resistance to thyroid hormone β, RTHβ) showed elevated free tri-iodothyronine/thyroxine levels with normal thyroid-stimulating hormone levels, whereas healthy controls showed normal thyroid hormone levels. Imaging revealed smaller pituitary size in RTHβ patients in comparison to healthy controls (F(1,35) = 7.05, P = 0.012, partial η2 = 0.17).
Conclusion
RTHβ subjects have impaired sensitivity to thyroid hormones, along with decreased size of the pituitary gland.
Identifiants
pubmed: 34860176
doi: 10.1530/EC-21-0473
pii: EC-21-0473.R2
pmc: PMC8789019
doi:
pii:
Types de publication
Journal Article
Langues
eng
Références
Biochim Biophys Acta. 2013 Jul;1830(7):4004-8
pubmed: 23528896
J Clin Invest. 2014 Jan;124(1):321-7
pubmed: 24316972
BMJ Case Rep. 2019 Jul 19;12(7):
pubmed: 31326901
J Clin Endocrinol Metab. 2015 Jul;100(7):2511-4
pubmed: 25867808
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7329-33
pubmed: 3118365
Endocrinol Diabetes Metab Case Rep. 2015;2015:150056
pubmed: 26279852
Clin Pediatr Endocrinol. 2010 Oct;19(4):91-9
pubmed: 23926384
J Clin Endocrinol Metab. 1976 May;42(5):817-22
pubmed: 1270575
J Clin Endocrinol Metab. 2001 Nov;86(11):5572-6
pubmed: 11701737
Thyroid. 2012 Jan;22(1):101-2
pubmed: 22150559
Thyroid. 1998 Aug;8(8):679-82
pubmed: 9737363
Int J Neurosci. 2020 Aug 5;:1-5
pubmed: 32727243
Thyroid. 2001 Mar;11(3):281-91
pubmed: 11327621
Front Endocrinol (Lausanne). 2016 Apr 26;7:35
pubmed: 27199892
Methods Mol Biol. 2018;1801:225-240
pubmed: 29892828
Fertil Steril. 1983 Sep;40(3):389-92
pubmed: 6411499
J Clin Invest. 1999 Aug;104(3):291-300
pubmed: 10430610
J Clin Endocrinol Metab. 1993 Apr;76(4):1025-30
pubmed: 8473377
J Clin Endocrinol Metab. 2016 Jul;101(7):2636-9
pubmed: 27381958
Thyroid. 1994 Summer;4(2):225-32
pubmed: 7920008
Endocrinol Diabetes Metab Case Rep. 2018 Dec 5;2018:
pubmed: 30530874
Hormones (Athens). 2016 Oct;15(4):534-539
pubmed: 28222413
South Med J. 1983 Apr;76(4):529-31
pubmed: 6682252
Asian J Neurosurg. 2011 Jul;6(2):99-100
pubmed: 22347332
Clin Case Rep. 2020 Apr 16;8(7):1317-1318
pubmed: 32695387
PLoS One. 2017 Jul 6;12(7):e0179590
pubmed: 28683072
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Thyroid. 2016 Dec;26(12):1804-1806
pubmed: 27758132
Medicine (Baltimore). 2020 Feb;99(8):e19222
pubmed: 32080117
Nat Rev Endocrinol. 2014 Oct;10(10):582-91
pubmed: 25135573
Ann Intern Med. 1995 Oct 15;123(8):572-83
pubmed: 7677297
Behav Neurol. 2000;12(4):191-200
pubmed: 11568431
J Formos Med Assoc. 2020 Oct;119(10):1546-1549
pubmed: 32505587
Pituitary. 2005;8(2):99-103
pubmed: 16195776